Lymphoplasmacytic and eosinophilic enteritis with or without globule leukocyte hyperplasia in 4 goats

Mariya O. Pitel, Meera C. Heller, Jerry R. Roberson, Erica C. McKenzie, Devinn M. Sinnott, Verena K. Affolter

Research output: Contribution to journalArticlepeer-review


Four, mature, client-owned goats were presented to referral hospitals for recurrent diarrhea despite treatment for intestinal parasitism. Common clinical findings included diarrhea, poor condition, neutrophilia, and hypoalbuminemia. Testing for common infectious causes of diarrhea in goats was negative. Ultrasonography and computed tomography in 2 cases was suggestive of enteritis, including thickened intestinal walls and fluid filled, dilated small intestines, respectively. Lymphoplasmacytic and eosinophilic enteritis (LEE) was ultimately diagnosed on intestinal biopsy histopathology based on the presence of small intestinal villous blunting and increased numbers of lymphocytes and eosinophils predominantly within the lamina propria. Numerous globule leukocytes were also noted on histopathology in 3 cases. All goats responded favorably to corticosteroid treatment with weight gain and resolution of diarrhea and clinicopathologic abnormalities. Relapses occurred, and complete cure was difficult to achieve. Reported in other species, this series describes the clinical presentation, diagnosis, and treatment of LEE in adult goats.

Original languageEnglish (US)
Pages (from-to)1620-1625
Number of pages6
JournalJournal of Veterinary Internal Medicine
Issue number3
StatePublished - May 1 2021


  • caprine
  • hypoalbuminemia
  • inflammatory bowel disease
  • weight loss

ASJC Scopus subject areas

  • veterinary(all)


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