Lymphoid immunohistochemistry of macaque primates

L. D. Ormerod, K. G. Osborn, L. J. Lowenstine, P. R. Meyer, J. W. Parker, R. E. Smith, C. R. Taylor

Research output: Contribution to journalArticle

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Abstract

The immunohistochemical localizations of 53 monoclonal antibodies with specificities expressed in human lymphoid tissue were investigated on lymph node tissues from Macaca mulatta, M. speciosa, and M. fascicularis using immunoperoxidase techniques. Thirty antibodies showed comparative cross-reactivity. The micro-anatomic distribution of these antigens was closely homologous to that observed in man and antigen densities appeared to be similar. A useful monoclonal antibody panel for immunopathological investigations in macaques was, thereby, defined. Of several pan-T antibodies studied, only OKT11 (CD2) showed cross-reactivity. A detailed analysis of the immunocyto-architecture of five rhesus lymph nodes was undertaken. Automated flow cytometry of M. mulatta and M. speciosa peripheral blood showed a broadly similar pattern to man.

Original languageEnglish (US)
Pages (from-to)435-442
Number of pages8
JournalClinical and Experimental Immunology
Volume74
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology

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    Ormerod, L. D., Osborn, K. G., Lowenstine, L. J., Meyer, P. R., Parker, J. W., Smith, R. E., & Taylor, C. R. (1988). Lymphoid immunohistochemistry of macaque primates. Clinical and Experimental Immunology, 74(3), 435-442.