Lymphoid follicles in the gastric mucosa of dogs. Distribution and lymphocyte phenotypes

Øyvor Kolbjørnsen, Charles Mc L Press, Peter F Moore, Thor Landsverk

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The occurrence and distribution of lymphoid follicles within the stomachs of 36 dogs that dis not have macroscopic gastric lesions are presented. The dogs ranged in age from less than 1 year to over 13 years. The number of follicles varied between the different regions of the stomach, being most numerous (15.6 follicles cm-2) and uniform in size (about 1 mm in diameter) in the fundus. The number and size of follicles in the antrum varied widely between dogs. Age-related changes in the distribution of follicles were not found following simple linear regression analysis. The phenotypes of lymphocytes in gastric lymphoid follicles of nine dogs aged from less than 1 year to 5 years were determined using monoclonal antibodies specific for canine leucocyte antigens and an indirect immunoperoxidase technique. The follicles had an organized distribution of lymphocytes subsets in that a predominantly B cell area contained some CD4+ cells and very few CD8+ cells and was adjacent to an area containing mostly T cells. Computer-assisted morphometric analysis was used to quantify the overall presence of the various lymphocyte subpopulations. Follicles in the fundus and body regions possessed similar percentages of lymphocytes averaging 42%, 22% and 3% of the area occupied by B cells, CD4+ and CD8+ cells, respectively. It is concluded that lymphoid follicles are a normal constituent of the canine gastric mucosa and possess a lymphocyte composition similar to that reported by others for solitary intestinal follicles.

Original languageEnglish (US)
Pages (from-to)299-312
Number of pages14
JournalVeterinary Immunology and Immunopathology
Volume40
Issue number4
DOIs
StatePublished - 1994

Fingerprint

gastric mucosa
Gastric Mucosa
Stomach
lymphocytes
Dogs
Lymphocytes
Phenotype
phenotype
dogs
Lymphocyte Subsets
stomach
Canidae
B-Lymphocytes
Body Regions
B-lymphocytes
HLA Antigens
Immunoenzyme Techniques
Linear Models
body regions
Monoclonal Antibodies

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Lymphoid follicles in the gastric mucosa of dogs. Distribution and lymphocyte phenotypes. / Kolbjørnsen, Øyvor; Press, Charles Mc L; Moore, Peter F; Landsverk, Thor.

In: Veterinary Immunology and Immunopathology, Vol. 40, No. 4, 1994, p. 299-312.

Research output: Contribution to journalArticle

Kolbjørnsen, Øyvor ; Press, Charles Mc L ; Moore, Peter F ; Landsverk, Thor. / Lymphoid follicles in the gastric mucosa of dogs. Distribution and lymphocyte phenotypes. In: Veterinary Immunology and Immunopathology. 1994 ; Vol. 40, No. 4. pp. 299-312.
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