Lymphocyte transformation and interferon production as measures of cellular immunity in lymphoma patients.

A. M. Arvin, Richard B Pollard, L. E. Rasmussen, K. H. Rand, T. C. Merigan

Research output: Contribution to journalArticle


Our studies of in vitro cellular immune responses to herpesviruses have shown that, before treatment, lymphoma patients have decreased transformation to varicella-zoster virus antigen compared to herpes simplex virus and cytomegalovirus antigens. Interferon production to varicella-zoster virus and cytomegalovirus antigens is also decreased. During the first six months of treatment, decreased lymphocyte transformation and interferon production to all herpesviral antigens was observed. Among patients in long-term remission, recovery from the suppression associated with treatment was noted except that interferon production to varicella-zoster virus antigen remained decreased.

Original languageEnglish (US)
Pages (from-to)745-751
Number of pages7
JournalIARC scientific publications
Issue number24 Pt 2
StatePublished - 1978
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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