Lymphocyte blastogenesis in bluetongue virus or Mycobacterium bovis-inoculated bovine fetuses

Nigel J Maclachlan, Caroline E. Schore, Bennie Osburn

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bovine fetuses were inoculated with Mycobacterium bovis, bluetongue virus or placebo at approximately 125 days of gestation, and blastogenic responses of peripheral blood lymphocytes and lymph node cells were determined at various time intervals after inoculation. Lymphocytes from all fetuses were stimulated by phytohemagglutinin, concanavalin A, and pokeweed mitogen, and peripheral blood lymphocytes gave consistently greater stimulation indices than did prescapular lymph node cells. Bluetongue virus infection did not consistently suppress mitogen induced lymphocyte blastogenesis. Lymphocytes taken from fetuses at 20 or 50 days after Mycobacterium bovis inoculation were not stimulated by purified protein derivative (PPD), whereas lymphocytes taken from adult cattle at similar intervals after Mycobacterium bovis inoculation were stimulated by PPD. Although lymphocytes from bovine fetuses may be stimulated by mitogens, antigen specific blastogenesis to a known inducer of cellular immunity was not detected by 175 days of gestation.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume7
Issue number1
DOIs
StatePublished - 1984

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Bluetongue virus
Mycobacterium bovis
lymphocyte proliferation
Lymphocyte Activation
fetus
Fetus
lymphocytes
Lymphocytes
cattle
Mitogens
lymph nodes
Lymph Nodes
pregnancy
Pokeweed Mitogens
Pregnancy
Phytolacca americana
phytohemagglutinin
blood
Phytohemagglutinins
Virus Diseases

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Lymphocyte blastogenesis in bluetongue virus or Mycobacterium bovis-inoculated bovine fetuses. / Maclachlan, Nigel J; Schore, Caroline E.; Osburn, Bennie.

In: Veterinary Immunology and Immunopathology, Vol. 7, No. 1, 1984, p. 11-18.

Research output: Contribution to journalArticle

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