Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls

Joseph R. Magliozzi, Dorothy Gietzen, Richard J Maddock, Deanna Haack, Allen R. Doran, Theodore Goodman, Philip G. Weiler

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Abstract

Values of binding maximum (Bmax) and dissociation constant (Kd) of (-)3-[125I]iodocyanopindolol (ICYP) were determined in β-adrenergic receptors of membranes of peripheral lymphocytes in 32 patients with unipolar depression (DSM-III-R) and 31 normal controls. Results were analyzed by a two-way Analysis of Covariance method. A significant difference was noted for group assignment (patient versus control, p < 0.05). Mean Bmax (fmol ICYP bound/mg lymphocyte membrane fraction total protein) of patients was 31.9 ± 3.84 (se) and controls 46.3 ± 3.92 (se). A significant interaction was found between group membership and gender (p < 0.05). In the female patient group (n = 14), mean Bmax was 30.5 ± 5.79 (se); in female controls, mean Bmax was 56.0 ± 5.15(SE). Differences between male patients and male controls were not significant. Mean values of Kd (pmol/liter) showed a trend for patient values to be lower than control values [69.0 ± 73.66 (se) versus 108.5 ± 14.42 (se), respectively]. A significant inverse relationship was noted between lymphocyte β-receptor Bmax and frequency of panic attacks during the depressive episode in 18 patients (p = 0.05). No relationship was found between values of Kd and frequency of panic attacks in these patients. Thus, preliminary evidence is provided for relationships among altered β-adrenergic receptor binding, gender, and indices of panic-anxiety in unipolar depressed patients.

Original languageEnglish (US)
Pages (from-to)15-25
Number of pages11
JournalBiological Psychiatry
Volume26
Issue number1
DOIs
StatePublished - 1989

Fingerprint

Depressive Disorder
Lymphocytes
Iodocyanopindolol
Panic Disorder
Adrenergic Receptors
Dissociative Disorders
Panic
Membranes
Diagnostic and Statistical Manual of Mental Disorders
Anxiety

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls. / Magliozzi, Joseph R.; Gietzen, Dorothy; Maddock, Richard J; Haack, Deanna; Doran, Allen R.; Goodman, Theodore; Weiler, Philip G.

In: Biological Psychiatry, Vol. 26, No. 1, 1989, p. 15-25.

Research output: Contribution to journalArticle

Magliozzi, Joseph R. ; Gietzen, Dorothy ; Maddock, Richard J ; Haack, Deanna ; Doran, Allen R. ; Goodman, Theodore ; Weiler, Philip G. / Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls. In: Biological Psychiatry. 1989 ; Vol. 26, No. 1. pp. 15-25.
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