Abstract
Values of binding maximum (Bmax) and dissociation constant (Kd) of (-)3-[125I]iodocyanopindolol (ICYP) were determined in β-adrenergic receptors of membranes of peripheral lymphocytes in 32 patients with unipolar depression (DSM-III-R) and 31 normal controls. Results were analyzed by a two-way Analysis of Covariance method. A significant difference was noted for group assignment (patient versus control, p < 0.05). Mean Bmax (fmol ICYP bound/mg lymphocyte membrane fraction total protein) of patients was 31.9 ± 3.84 (se) and controls 46.3 ± 3.92 (se). A significant interaction was found between group membership and gender (p < 0.05). In the female patient group (n = 14), mean Bmax was 30.5 ± 5.79 (se); in female controls, mean Bmax was 56.0 ± 5.15(SE). Differences between male patients and male controls were not significant. Mean values of Kd (pmol/liter) showed a trend for patient values to be lower than control values [69.0 ± 73.66 (se) versus 108.5 ± 14.42 (se), respectively]. A significant inverse relationship was noted between lymphocyte β-receptor Bmax and frequency of panic attacks during the depressive episode in 18 patients (p = 0.05). No relationship was found between values of Kd and frequency of panic attacks in these patients. Thus, preliminary evidence is provided for relationships among altered β-adrenergic receptor binding, gender, and indices of panic-anxiety in unipolar depressed patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15-25 |
| Number of pages | 11 |
| Journal | Biological Psychiatry |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Biological Psychiatry
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Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls. / Magliozzi, Joseph R.; Gietzen, Dorothy; Maddock, Richard J; Haack, Deanna; Doran, Allen R.; Goodman, Theodore; Weiler, Philip G.
In: Biological Psychiatry, Vol. 26, No. 1, 1989, p. 15-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls
AU - Magliozzi, Joseph R.
AU - Gietzen, Dorothy
AU - Maddock, Richard J
AU - Haack, Deanna
AU - Doran, Allen R.
AU - Goodman, Theodore
AU - Weiler, Philip G.
PY - 1989
Y1 - 1989
N2 - Values of binding maximum (Bmax) and dissociation constant (Kd) of (-)3-[125I]iodocyanopindolol (ICYP) were determined in β-adrenergic receptors of membranes of peripheral lymphocytes in 32 patients with unipolar depression (DSM-III-R) and 31 normal controls. Results were analyzed by a two-way Analysis of Covariance method. A significant difference was noted for group assignment (patient versus control, p < 0.05). Mean Bmax (fmol ICYP bound/mg lymphocyte membrane fraction total protein) of patients was 31.9 ± 3.84 (se) and controls 46.3 ± 3.92 (se). A significant interaction was found between group membership and gender (p < 0.05). In the female patient group (n = 14), mean Bmax was 30.5 ± 5.79 (se); in female controls, mean Bmax was 56.0 ± 5.15(SE). Differences between male patients and male controls were not significant. Mean values of Kd (pmol/liter) showed a trend for patient values to be lower than control values [69.0 ± 73.66 (se) versus 108.5 ± 14.42 (se), respectively]. A significant inverse relationship was noted between lymphocyte β-receptor Bmax and frequency of panic attacks during the depressive episode in 18 patients (p = 0.05). No relationship was found between values of Kd and frequency of panic attacks in these patients. Thus, preliminary evidence is provided for relationships among altered β-adrenergic receptor binding, gender, and indices of panic-anxiety in unipolar depressed patients.
AB - Values of binding maximum (Bmax) and dissociation constant (Kd) of (-)3-[125I]iodocyanopindolol (ICYP) were determined in β-adrenergic receptors of membranes of peripheral lymphocytes in 32 patients with unipolar depression (DSM-III-R) and 31 normal controls. Results were analyzed by a two-way Analysis of Covariance method. A significant difference was noted for group assignment (patient versus control, p < 0.05). Mean Bmax (fmol ICYP bound/mg lymphocyte membrane fraction total protein) of patients was 31.9 ± 3.84 (se) and controls 46.3 ± 3.92 (se). A significant interaction was found between group membership and gender (p < 0.05). In the female patient group (n = 14), mean Bmax was 30.5 ± 5.79 (se); in female controls, mean Bmax was 56.0 ± 5.15(SE). Differences between male patients and male controls were not significant. Mean values of Kd (pmol/liter) showed a trend for patient values to be lower than control values [69.0 ± 73.66 (se) versus 108.5 ± 14.42 (se), respectively]. A significant inverse relationship was noted between lymphocyte β-receptor Bmax and frequency of panic attacks during the depressive episode in 18 patients (p = 0.05). No relationship was found between values of Kd and frequency of panic attacks in these patients. Thus, preliminary evidence is provided for relationships among altered β-adrenergic receptor binding, gender, and indices of panic-anxiety in unipolar depressed patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024309025&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(89)90004-8
DO - 10.1016/0006-3223(89)90004-8
M3 - Article
C2 - 2541807
AN - SCOPUS:0024309025
VL - 26
SP - 15
EP - 25
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 1
ER -