Lymphangiosarcoma in a young dog

J. E. Sagartz, Michael Dale Lairmore, D. Haines, S. E. Sheafor, C. G. Couto

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Lymphangiosarcoma was diagnosed from biopsy material obtained from an 8-week-old puppy with a progressively enlarging subcutaneous inguinal swelling. Histologically, the tumor was composed of endothelial cells immediately adjacent to large collagen bundles. Tumor cells formed irregular vascular channels which extended along the connective tissue investments of small vessels and nerves of the subcutis and deep dermis. Similar neoplastic tissue extensively infiltrated an inguinal lymph node. Neoplastic cells were immunohistochemically stained for factor 8-related antigen and were weakly positive when compared with several hemangiomas and hemangiosarcomas. Transmission electron microscopy revealed numerous micropinocytotic vesicles and a continuous basal lamina. The puppy was euthanatized at 8 months of age due to severe septic polyarthritis. Lymphangiosarcoma was documented at the site of the original tumor as well as in the axillary lymph node at necropsy.

Original languageEnglish (US)
Pages (from-to)353-356
Number of pages4
JournalVeterinary Pathology
Issue number3
StatePublished - May 1996
Externally publishedYes


  • Dogs
  • Lymphangiosarcoma
  • Neoplasia

ASJC Scopus subject areas

  • veterinary(all)


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