Lymph node aspirate from a California wine-country dog

Jennifer L. Johns, Jennifer L. Strasser, Joseph G. Zinkl, Mary M Christopher

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 4-year-old, male Golden Retriever was presented to the Veterinary Medical Teaching Hospital at the University of California-Davis with a history of lethargy, inappetance, and vomiting. The patient had generalized lymphadenomegaly, marked thrombocytopenia, mild anemia, and moderate hypoalbuminemia. Moderate to marked histiocytic inflammation and lymphocytic-plasmacytic reactivity of the mesenteric, left popliteal, and right mandibular lymph nodes were diagnosed cytologically. Many macrophages contained granular to amorphous material of a uniform blue color, occasionally in morula formation, suggestive of rickettsial organisms. Exposure to raw trout was subsequently documented, leading to a presumptive diagnosis of salmon poisoning disease (SPD). The patient responded quickly to doxycycline therapy for the causative agent of SPD (Neorickettsia helminthoeca). SPD should be considered as a differential diagnosis for a canine patient with clinical signs of vomiting, diarrhea, lethargy, and lymphadenomegaly; laboratory findings of thrombocytopenia and hypoalbuminemia; and potential exposure to raw fish from an endemic area. The cytologic finding of rickettsial inclusions within lymph node macrophages is reportedly seen within a majority of SPD cases and can be valuable in supporting a clinical suspicion of SPD, as it was in this case.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalVeterinary Clinical Pathology
Volume35
Issue number2
DOIs
StatePublished - Jun 2006

Fingerprint

Wine
Salmon
Poisoning
salmon
lymph nodes
wines
poisoning
Lymph Nodes
Dogs
dogs
Hypoalbuminemia
Lethargy
Macrophages
thrombocytopenia
vomiting
Thrombocytopenia
Neorickettsia
Neorickettsia helminthoeca
Vomiting
macrophages

Keywords

  • Histiocytic inflammation
  • Lymph node cytology
  • Morulae
  • Nanophyetus salmincola
  • Neorickettsia helminthoeca
  • Salmon poisoning disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Lymph node aspirate from a California wine-country dog. / Johns, Jennifer L.; Strasser, Jennifer L.; Zinkl, Joseph G.; Christopher, Mary M.

In: Veterinary Clinical Pathology, Vol. 35, No. 2, 06.2006, p. 243-246.

Research output: Contribution to journalArticle

Johns, Jennifer L. ; Strasser, Jennifer L. ; Zinkl, Joseph G. ; Christopher, Mary M. / Lymph node aspirate from a California wine-country dog. In: Veterinary Clinical Pathology. 2006 ; Vol. 35, No. 2. pp. 243-246.
@article{0a08f13e0c564a32a66d9ac24b205349,
title = "Lymph node aspirate from a California wine-country dog",
abstract = "A 4-year-old, male Golden Retriever was presented to the Veterinary Medical Teaching Hospital at the University of California-Davis with a history of lethargy, inappetance, and vomiting. The patient had generalized lymphadenomegaly, marked thrombocytopenia, mild anemia, and moderate hypoalbuminemia. Moderate to marked histiocytic inflammation and lymphocytic-plasmacytic reactivity of the mesenteric, left popliteal, and right mandibular lymph nodes were diagnosed cytologically. Many macrophages contained granular to amorphous material of a uniform blue color, occasionally in morula formation, suggestive of rickettsial organisms. Exposure to raw trout was subsequently documented, leading to a presumptive diagnosis of salmon poisoning disease (SPD). The patient responded quickly to doxycycline therapy for the causative agent of SPD (Neorickettsia helminthoeca). SPD should be considered as a differential diagnosis for a canine patient with clinical signs of vomiting, diarrhea, lethargy, and lymphadenomegaly; laboratory findings of thrombocytopenia and hypoalbuminemia; and potential exposure to raw fish from an endemic area. The cytologic finding of rickettsial inclusions within lymph node macrophages is reportedly seen within a majority of SPD cases and can be valuable in supporting a clinical suspicion of SPD, as it was in this case.",
keywords = "Histiocytic inflammation, Lymph node cytology, Morulae, Nanophyetus salmincola, Neorickettsia helminthoeca, Salmon poisoning disease",
author = "Johns, {Jennifer L.} and Strasser, {Jennifer L.} and Zinkl, {Joseph G.} and Christopher, {Mary M}",
year = "2006",
month = "6",
doi = "10.1111/j.1939-165X.2006.tb00123.x",
language = "English (US)",
volume = "35",
pages = "243--246",
journal = "Veterinary Clinical Pathology",
issn = "0275-6382",
publisher = "American Society for Veterinary Clinical Pathology",
number = "2",

}

TY - JOUR

T1 - Lymph node aspirate from a California wine-country dog

AU - Johns, Jennifer L.

AU - Strasser, Jennifer L.

AU - Zinkl, Joseph G.

AU - Christopher, Mary M

PY - 2006/6

Y1 - 2006/6

N2 - A 4-year-old, male Golden Retriever was presented to the Veterinary Medical Teaching Hospital at the University of California-Davis with a history of lethargy, inappetance, and vomiting. The patient had generalized lymphadenomegaly, marked thrombocytopenia, mild anemia, and moderate hypoalbuminemia. Moderate to marked histiocytic inflammation and lymphocytic-plasmacytic reactivity of the mesenteric, left popliteal, and right mandibular lymph nodes were diagnosed cytologically. Many macrophages contained granular to amorphous material of a uniform blue color, occasionally in morula formation, suggestive of rickettsial organisms. Exposure to raw trout was subsequently documented, leading to a presumptive diagnosis of salmon poisoning disease (SPD). The patient responded quickly to doxycycline therapy for the causative agent of SPD (Neorickettsia helminthoeca). SPD should be considered as a differential diagnosis for a canine patient with clinical signs of vomiting, diarrhea, lethargy, and lymphadenomegaly; laboratory findings of thrombocytopenia and hypoalbuminemia; and potential exposure to raw fish from an endemic area. The cytologic finding of rickettsial inclusions within lymph node macrophages is reportedly seen within a majority of SPD cases and can be valuable in supporting a clinical suspicion of SPD, as it was in this case.

AB - A 4-year-old, male Golden Retriever was presented to the Veterinary Medical Teaching Hospital at the University of California-Davis with a history of lethargy, inappetance, and vomiting. The patient had generalized lymphadenomegaly, marked thrombocytopenia, mild anemia, and moderate hypoalbuminemia. Moderate to marked histiocytic inflammation and lymphocytic-plasmacytic reactivity of the mesenteric, left popliteal, and right mandibular lymph nodes were diagnosed cytologically. Many macrophages contained granular to amorphous material of a uniform blue color, occasionally in morula formation, suggestive of rickettsial organisms. Exposure to raw trout was subsequently documented, leading to a presumptive diagnosis of salmon poisoning disease (SPD). The patient responded quickly to doxycycline therapy for the causative agent of SPD (Neorickettsia helminthoeca). SPD should be considered as a differential diagnosis for a canine patient with clinical signs of vomiting, diarrhea, lethargy, and lymphadenomegaly; laboratory findings of thrombocytopenia and hypoalbuminemia; and potential exposure to raw fish from an endemic area. The cytologic finding of rickettsial inclusions within lymph node macrophages is reportedly seen within a majority of SPD cases and can be valuable in supporting a clinical suspicion of SPD, as it was in this case.

KW - Histiocytic inflammation

KW - Lymph node cytology

KW - Morulae

KW - Nanophyetus salmincola

KW - Neorickettsia helminthoeca

KW - Salmon poisoning disease

UR - http://www.scopus.com/inward/record.url?scp=33745640306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745640306&partnerID=8YFLogxK

U2 - 10.1111/j.1939-165X.2006.tb00123.x

DO - 10.1111/j.1939-165X.2006.tb00123.x

M3 - Article

C2 - 16783722

AN - SCOPUS:33745640306

VL - 35

SP - 243

EP - 246

JO - Veterinary Clinical Pathology

JF - Veterinary Clinical Pathology

SN - 0275-6382

IS - 2

ER -