Abstract
A 4-year-old, male Golden Retriever was presented to the Veterinary Medical Teaching Hospital at the University of California-Davis with a history of lethargy, inappetance, and vomiting. The patient had generalized lymphadenomegaly, marked thrombocytopenia, mild anemia, and moderate hypoalbuminemia. Moderate to marked histiocytic inflammation and lymphocytic-plasmacytic reactivity of the mesenteric, left popliteal, and right mandibular lymph nodes were diagnosed cytologically. Many macrophages contained granular to amorphous material of a uniform blue color, occasionally in morula formation, suggestive of rickettsial organisms. Exposure to raw trout was subsequently documented, leading to a presumptive diagnosis of salmon poisoning disease (SPD). The patient responded quickly to doxycycline therapy for the causative agent of SPD (Neorickettsia helminthoeca). SPD should be considered as a differential diagnosis for a canine patient with clinical signs of vomiting, diarrhea, lethargy, and lymphadenomegaly; laboratory findings of thrombocytopenia and hypoalbuminemia; and potential exposure to raw fish from an endemic area. The cytologic finding of rickettsial inclusions within lymph node macrophages is reportedly seen within a majority of SPD cases and can be valuable in supporting a clinical suspicion of SPD, as it was in this case.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-246 |
| Number of pages | 4 |
| Journal | Veterinary Clinical Pathology |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2006 |
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Keywords
- Histiocytic inflammation
- Lymph node cytology
- Morulae
- Nanophyetus salmincola
- Neorickettsia helminthoeca
- Salmon poisoning disease
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- veterinary(all)
Cite this
Lymph node aspirate from a California wine-country dog. / Johns, Jennifer L.; Strasser, Jennifer L.; Zinkl, Joseph G.; Christopher, Mary M.
In: Veterinary Clinical Pathology, Vol. 35, No. 2, 06.2006, p. 243-246.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymph node aspirate from a California wine-country dog
AU - Johns, Jennifer L.
AU - Strasser, Jennifer L.
AU - Zinkl, Joseph G.
AU - Christopher, Mary M
PY - 2006/6
Y1 - 2006/6
N2 - A 4-year-old, male Golden Retriever was presented to the Veterinary Medical Teaching Hospital at the University of California-Davis with a history of lethargy, inappetance, and vomiting. The patient had generalized lymphadenomegaly, marked thrombocytopenia, mild anemia, and moderate hypoalbuminemia. Moderate to marked histiocytic inflammation and lymphocytic-plasmacytic reactivity of the mesenteric, left popliteal, and right mandibular lymph nodes were diagnosed cytologically. Many macrophages contained granular to amorphous material of a uniform blue color, occasionally in morula formation, suggestive of rickettsial organisms. Exposure to raw trout was subsequently documented, leading to a presumptive diagnosis of salmon poisoning disease (SPD). The patient responded quickly to doxycycline therapy for the causative agent of SPD (Neorickettsia helminthoeca). SPD should be considered as a differential diagnosis for a canine patient with clinical signs of vomiting, diarrhea, lethargy, and lymphadenomegaly; laboratory findings of thrombocytopenia and hypoalbuminemia; and potential exposure to raw fish from an endemic area. The cytologic finding of rickettsial inclusions within lymph node macrophages is reportedly seen within a majority of SPD cases and can be valuable in supporting a clinical suspicion of SPD, as it was in this case.
AB - A 4-year-old, male Golden Retriever was presented to the Veterinary Medical Teaching Hospital at the University of California-Davis with a history of lethargy, inappetance, and vomiting. The patient had generalized lymphadenomegaly, marked thrombocytopenia, mild anemia, and moderate hypoalbuminemia. Moderate to marked histiocytic inflammation and lymphocytic-plasmacytic reactivity of the mesenteric, left popliteal, and right mandibular lymph nodes were diagnosed cytologically. Many macrophages contained granular to amorphous material of a uniform blue color, occasionally in morula formation, suggestive of rickettsial organisms. Exposure to raw trout was subsequently documented, leading to a presumptive diagnosis of salmon poisoning disease (SPD). The patient responded quickly to doxycycline therapy for the causative agent of SPD (Neorickettsia helminthoeca). SPD should be considered as a differential diagnosis for a canine patient with clinical signs of vomiting, diarrhea, lethargy, and lymphadenomegaly; laboratory findings of thrombocytopenia and hypoalbuminemia; and potential exposure to raw fish from an endemic area. The cytologic finding of rickettsial inclusions within lymph node macrophages is reportedly seen within a majority of SPD cases and can be valuable in supporting a clinical suspicion of SPD, as it was in this case.
KW - Histiocytic inflammation
KW - Lymph node cytology
KW - Morulae
KW - Nanophyetus salmincola
KW - Neorickettsia helminthoeca
KW - Salmon poisoning disease
UR - http://www.scopus.com/inward/record.url?scp=33745640306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745640306&partnerID=8YFLogxK
U2 - 10.1111/j.1939-165X.2006.tb00123.x
DO - 10.1111/j.1939-165X.2006.tb00123.x
M3 - Article
C2 - 16783722
AN - SCOPUS:33745640306
VL - 35
SP - 243
EP - 246
JO - Veterinary Clinical Pathology
JF - Veterinary Clinical Pathology
SN - 0275-6382
IS - 2
ER -