Lyme neuroborreliosis in 2 horses

Denise Imai, B. C. Barr, B. Daft, J. J. Bertone, S. Feng, Emir Hodzic, J. M. Johnston, K. J. Olsen, Stephen W Barthold

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Lyme neuroborreliosis-characterized as chronic, necrosuppurative to nonsuppurative, perivascular to diffuse meningoradiculoneuritis-was diagnosed in 2 horses with progressive neurologic disease. In 1 horse, Borrelia burgdorferi sensu stricto was identified by polymerase chain reaction amplification of B burgdorferi sensu stricto-specific gene targets (ospA, ospC, flaB, dbpA, arp). Highest spirochetal burdens were in tissues with inflammation, including spinal cord, muscle, and joint capsule. Sequence analysis of ospA, ospC, and flaB revealed 99.9% sequence identity to the respective genes in B burgdorferi strain 297, an isolate from a human case of neuroborreliosis. In both horses, spirochetes were visualized in affected tissues with Steiner silver impregnation and by immunohistochemistry, predominantly within the dense collagenous tissue of the dura mater and leptomeninges.

Original languageEnglish (US)
Pages (from-to)1151-1157
Number of pages7
JournalVeterinary Pathology
Issue number6
StatePublished - Nov 29 2011


  • Borrelia burgdorferi
  • equine
  • Lyme disease
  • meningitis
  • neuroborreliosis
  • polyradiculoneuritis

ASJC Scopus subject areas

  • veterinary(all)


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