Lyme borreliosis in selected strains and ages of laboratory mice

Stephen W Barthold, Deborah S. Beck, George M. Hansen, Gordon A. Terwilliger, Kathleen D. Moody

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

The susceptibility of laboratory mice to Borrelia burgdorferi was evaluated for selected genotypes and ages. C3H/He, SWR, C57BL/6, SJL, and BALB/c mice inoculated at age 3 days developed uniformly severe polyarthritis at 30 days after intraperitoneal inoculation. Mice inoculated at age 3 weeks also developed polyarthritis, but severity was influenced by genotype, with C3H/He and SWR mice the most severely affected. Susceptible strains developed higher IgG ELISA antibody titers to B. burgdorferi than did resistant mice. Adult (12 weeks) C3H/He mice were also susceptible, but arthritis was not as severe as in those inoculated at age 3 weeks. SKH (hairless) mice developed polyarthritis but not skin disease when inoculated intradermally. Carditis occurred frequently among C3H/He, BALB/c, and hairless mice and in some SWR mice but not in C57BL/6 or SJL mice. This study demonstrates that severity of Lyme borreliosis is age- and genotype-dependent and that laboratory mice are a potentially valuable model.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Infectious Diseases
Volume162
Issue number1
StatePublished - Jul 1990
Externally publishedYes

Fingerprint

Lyme Disease
Arthritis
Hairless Mouse
Borrelia burgdorferi
Genotype
Inbred C3H Mouse
Myocarditis
Skin Diseases
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antibodies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Barthold, S. W., Beck, D. S., Hansen, G. M., Terwilliger, G. A., & Moody, K. D. (1990). Lyme borreliosis in selected strains and ages of laboratory mice. Journal of Infectious Diseases, 162(1), 133-138.

Lyme borreliosis in selected strains and ages of laboratory mice. / Barthold, Stephen W; Beck, Deborah S.; Hansen, George M.; Terwilliger, Gordon A.; Moody, Kathleen D.

In: Journal of Infectious Diseases, Vol. 162, No. 1, 07.1990, p. 133-138.

Research output: Contribution to journalArticle

Barthold, SW, Beck, DS, Hansen, GM, Terwilliger, GA & Moody, KD 1990, 'Lyme borreliosis in selected strains and ages of laboratory mice', Journal of Infectious Diseases, vol. 162, no. 1, pp. 133-138.
Barthold SW, Beck DS, Hansen GM, Terwilliger GA, Moody KD. Lyme borreliosis in selected strains and ages of laboratory mice. Journal of Infectious Diseases. 1990 Jul;162(1):133-138.
Barthold, Stephen W ; Beck, Deborah S. ; Hansen, George M. ; Terwilliger, Gordon A. ; Moody, Kathleen D. / Lyme borreliosis in selected strains and ages of laboratory mice. In: Journal of Infectious Diseases. 1990 ; Vol. 162, No. 1. pp. 133-138.
@article{5a1b5e3de0a445d78afa7a3422396908,
title = "Lyme borreliosis in selected strains and ages of laboratory mice",
abstract = "The susceptibility of laboratory mice to Borrelia burgdorferi was evaluated for selected genotypes and ages. C3H/He, SWR, C57BL/6, SJL, and BALB/c mice inoculated at age 3 days developed uniformly severe polyarthritis at 30 days after intraperitoneal inoculation. Mice inoculated at age 3 weeks also developed polyarthritis, but severity was influenced by genotype, with C3H/He and SWR mice the most severely affected. Susceptible strains developed higher IgG ELISA antibody titers to B. burgdorferi than did resistant mice. Adult (12 weeks) C3H/He mice were also susceptible, but arthritis was not as severe as in those inoculated at age 3 weeks. SKH (hairless) mice developed polyarthritis but not skin disease when inoculated intradermally. Carditis occurred frequently among C3H/He, BALB/c, and hairless mice and in some SWR mice but not in C57BL/6 or SJL mice. This study demonstrates that severity of Lyme borreliosis is age- and genotype-dependent and that laboratory mice are a potentially valuable model.",
author = "Barthold, {Stephen W} and Beck, {Deborah S.} and Hansen, {George M.} and Terwilliger, {Gordon A.} and Moody, {Kathleen D.}",
year = "1990",
month = "7",
language = "English (US)",
volume = "162",
pages = "133--138",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Lyme borreliosis in selected strains and ages of laboratory mice

AU - Barthold, Stephen W

AU - Beck, Deborah S.

AU - Hansen, George M.

AU - Terwilliger, Gordon A.

AU - Moody, Kathleen D.

PY - 1990/7

Y1 - 1990/7

N2 - The susceptibility of laboratory mice to Borrelia burgdorferi was evaluated for selected genotypes and ages. C3H/He, SWR, C57BL/6, SJL, and BALB/c mice inoculated at age 3 days developed uniformly severe polyarthritis at 30 days after intraperitoneal inoculation. Mice inoculated at age 3 weeks also developed polyarthritis, but severity was influenced by genotype, with C3H/He and SWR mice the most severely affected. Susceptible strains developed higher IgG ELISA antibody titers to B. burgdorferi than did resistant mice. Adult (12 weeks) C3H/He mice were also susceptible, but arthritis was not as severe as in those inoculated at age 3 weeks. SKH (hairless) mice developed polyarthritis but not skin disease when inoculated intradermally. Carditis occurred frequently among C3H/He, BALB/c, and hairless mice and in some SWR mice but not in C57BL/6 or SJL mice. This study demonstrates that severity of Lyme borreliosis is age- and genotype-dependent and that laboratory mice are a potentially valuable model.

AB - The susceptibility of laboratory mice to Borrelia burgdorferi was evaluated for selected genotypes and ages. C3H/He, SWR, C57BL/6, SJL, and BALB/c mice inoculated at age 3 days developed uniformly severe polyarthritis at 30 days after intraperitoneal inoculation. Mice inoculated at age 3 weeks also developed polyarthritis, but severity was influenced by genotype, with C3H/He and SWR mice the most severely affected. Susceptible strains developed higher IgG ELISA antibody titers to B. burgdorferi than did resistant mice. Adult (12 weeks) C3H/He mice were also susceptible, but arthritis was not as severe as in those inoculated at age 3 weeks. SKH (hairless) mice developed polyarthritis but not skin disease when inoculated intradermally. Carditis occurred frequently among C3H/He, BALB/c, and hairless mice and in some SWR mice but not in C57BL/6 or SJL mice. This study demonstrates that severity of Lyme borreliosis is age- and genotype-dependent and that laboratory mice are a potentially valuable model.

UR - http://www.scopus.com/inward/record.url?scp=0025292436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025292436&partnerID=8YFLogxK

M3 - Article

C2 - 2141344

AN - SCOPUS:0025292436

VL - 162

SP - 133

EP - 138

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -