Lupus erythematosus and localized scleroderma coexistent at the same sites: A rare presentation of overlap syndrome of connective-tissue diseases

Anabella Pascucci, Peter J. Lynch, Nasim Fazel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Overlap syndromes are known to occur with connective-tissue diseases (CTDs). Rarely, the overlap occurs at the same tissue site. We report the case of a patient with clinical and histopathologic findings consistent with the presence of discoid lupus erythematosus (DLE) and localized scleroderma within the same lesions. Based on our case and other reported cases in the literature, the following features are common in patients with an overlap of lupus erythematosus (LE) and localized scleroderma: predilection for young women, photodistributed lesions, DLE, linear morphology clinically, and positivity along the dermoepidermal junction on direct immunofluorescence. Most patients showed good response to antimalarials, topical steroids, or systemic steroids.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalCutis
Volume97
Issue number5
StatePublished - 2016

Fingerprint

Localized Scleroderma
Discoid Lupus Erythematosus
Steroids
Direct Fluorescent Antibody Technique
Connective Tissue Diseases
Antimalarials
MASS syndrome

ASJC Scopus subject areas

  • Medicine(all)
  • Dermatology

Cite this

Lupus erythematosus and localized scleroderma coexistent at the same sites : A rare presentation of overlap syndrome of connective-tissue diseases. / Pascucci, Anabella; Lynch, Peter J.; Fazel, Nasim.

In: Cutis, Vol. 97, No. 5, 2016, p. 359-363.

Research output: Contribution to journalArticle

@article{152c35c7d166499f91145c486f96f9f3,
title = "Lupus erythematosus and localized scleroderma coexistent at the same sites: A rare presentation of overlap syndrome of connective-tissue diseases",
abstract = "Overlap syndromes are known to occur with connective-tissue diseases (CTDs). Rarely, the overlap occurs at the same tissue site. We report the case of a patient with clinical and histopathologic findings consistent with the presence of discoid lupus erythematosus (DLE) and localized scleroderma within the same lesions. Based on our case and other reported cases in the literature, the following features are common in patients with an overlap of lupus erythematosus (LE) and localized scleroderma: predilection for young women, photodistributed lesions, DLE, linear morphology clinically, and positivity along the dermoepidermal junction on direct immunofluorescence. Most patients showed good response to antimalarials, topical steroids, or systemic steroids.",
author = "Anabella Pascucci and Lynch, {Peter J.} and Nasim Fazel",
year = "2016",
language = "English (US)",
volume = "97",
pages = "359--363",
journal = "Cutis",
issn = "0011-4162",
publisher = "Quadrant Healthcom Inc.",
number = "5",

}

TY - JOUR

T1 - Lupus erythematosus and localized scleroderma coexistent at the same sites

T2 - A rare presentation of overlap syndrome of connective-tissue diseases

AU - Pascucci, Anabella

AU - Lynch, Peter J.

AU - Fazel, Nasim

PY - 2016

Y1 - 2016

N2 - Overlap syndromes are known to occur with connective-tissue diseases (CTDs). Rarely, the overlap occurs at the same tissue site. We report the case of a patient with clinical and histopathologic findings consistent with the presence of discoid lupus erythematosus (DLE) and localized scleroderma within the same lesions. Based on our case and other reported cases in the literature, the following features are common in patients with an overlap of lupus erythematosus (LE) and localized scleroderma: predilection for young women, photodistributed lesions, DLE, linear morphology clinically, and positivity along the dermoepidermal junction on direct immunofluorescence. Most patients showed good response to antimalarials, topical steroids, or systemic steroids.

AB - Overlap syndromes are known to occur with connective-tissue diseases (CTDs). Rarely, the overlap occurs at the same tissue site. We report the case of a patient with clinical and histopathologic findings consistent with the presence of discoid lupus erythematosus (DLE) and localized scleroderma within the same lesions. Based on our case and other reported cases in the literature, the following features are common in patients with an overlap of lupus erythematosus (LE) and localized scleroderma: predilection for young women, photodistributed lesions, DLE, linear morphology clinically, and positivity along the dermoepidermal junction on direct immunofluorescence. Most patients showed good response to antimalarials, topical steroids, or systemic steroids.

UR - http://www.scopus.com/inward/record.url?scp=85012225072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012225072&partnerID=8YFLogxK

M3 - Article

C2 - 27274545

AN - SCOPUS:85012225072

VL - 97

SP - 359

EP - 363

JO - Cutis

JF - Cutis

SN - 0011-4162

IS - 5

ER -