Lung clearance of 99mTc-DTPA aerosol in conscious sheep

William J. Hornof; Michael W. O'Callagham; Robert A. Gunther; Red Howard; Paul Fisher; Otto Raabe; Carroll E Cross

doi:10.1016/0034-5687(88)90095-3

Lung clearance of ^99mTc-DTPA aerosol in conscious sheep

William J. Hornof, Michael W. O'Callagham, Robert A. Gunther, Red Howard, Paul Fisher, Otto Raabe, Carroll E Cross

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

This study was initiated to determine the rate and characteristics of ⁹⁹Tc-DTPA clearance from the whole lung in a group of 9 sheep. Submicronic aerosol droplets were delivered to unsedated sheep held in sing-like frame. Best fits for clearance to single- and bioexponentials were calculated. The monoexponential T₅₀ for the aerosol clearance was 293 in ± 74 SD. Background correction was found to have a minimal effect (approx. 10%). Bioexponential fitting only marginally improved correlations in the 8 healthy sheep, but in one additional animal with clinical evidence of pneumonia, clearance was faster and biexponential fitting was substantially better. These clearance values in conscious sheep are longer than previous findings mwith ^99mTc-DTPA in anesthetized sheep. There appears to be a wide variation of radioaerosol ^99mTc-DTPA lung clearances among different species, sheep exhibiting a comparatively prolonged clearance profile.

Original language	English (US)
Pages (from-to)	375-389
Number of pages	15
Journal	Respiration Physiology
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(88)90095-3
State	Published - 1988

Keywords

Bronchoalvelor clearance
Respiratory epithelial permeability
Sheep

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

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10.1016/0034-5687(88)90095-3

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title = "Lung clearance of 99mTc-DTPA aerosol in conscious sheep",

abstract = "This study was initiated to determine the rate and characteristics of 99Tc-DTPA clearance from the whole lung in a group of 9 sheep. Submicronic aerosol droplets were delivered to unsedated sheep held in sing-like frame. Best fits for clearance to single- and bioexponentials were calculated. The monoexponential T50 for the aerosol clearance was 293 in ± 74 SD. Background correction was found to have a minimal effect (approx. 10%). Bioexponential fitting only marginally improved correlations in the 8 healthy sheep, but in one additional animal with clinical evidence of pneumonia, clearance was faster and biexponential fitting was substantially better. These clearance values in conscious sheep are longer than previous findings mwith 99mTc-DTPA in anesthetized sheep. There appears to be a wide variation of radioaerosol 99mTc-DTPA lung clearances among different species, sheep exhibiting a comparatively prolonged clearance profile.",

keywords = "Bronchoalvelor clearance, Respiratory epithelial permeability, Sheep",

author = "Hornof, {William J.} and O'Callagham, {Michael W.} and Gunther, {Robert A.} and Red Howard and Paul Fisher and Otto Raabe and Cross, {Carroll E}",

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AU - Hornof, William J.

AU - O'Callagham, Michael W.

AU - Gunther, Robert A.

AU - Howard, Red

AU - Fisher, Paul

AU - Raabe, Otto

AU - Cross, Carroll E

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N2 - This study was initiated to determine the rate and characteristics of 99Tc-DTPA clearance from the whole lung in a group of 9 sheep. Submicronic aerosol droplets were delivered to unsedated sheep held in sing-like frame. Best fits for clearance to single- and bioexponentials were calculated. The monoexponential T50 for the aerosol clearance was 293 in ± 74 SD. Background correction was found to have a minimal effect (approx. 10%). Bioexponential fitting only marginally improved correlations in the 8 healthy sheep, but in one additional animal with clinical evidence of pneumonia, clearance was faster and biexponential fitting was substantially better. These clearance values in conscious sheep are longer than previous findings mwith 99mTc-DTPA in anesthetized sheep. There appears to be a wide variation of radioaerosol 99mTc-DTPA lung clearances among different species, sheep exhibiting a comparatively prolonged clearance profile.

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KW - Respiratory epithelial permeability

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