Abstract
This study was initiated to determine the rate and characteristics of 99Tc-DTPA clearance from the whole lung in a group of 9 sheep. Submicronic aerosol droplets were delivered to unsedated sheep held in sing-like frame. Best fits for clearance to single- and bioexponentials were calculated. The monoexponential T50 for the aerosol clearance was 293 in ± 74 SD. Background correction was found to have a minimal effect (approx. 10%). Bioexponential fitting only marginally improved correlations in the 8 healthy sheep, but in one additional animal with clinical evidence of pneumonia, clearance was faster and biexponential fitting was substantially better. These clearance values in conscious sheep are longer than previous findings mwith 99mTc-DTPA in anesthetized sheep. There appears to be a wide variation of radioaerosol 99mTc-DTPA lung clearances among different species, sheep exhibiting a comparatively prolonged clearance profile.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 375-389 |
| Number of pages | 15 |
| Journal | Respiration Physiology |
| Volume | 72 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1988 |
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Keywords
- Bronchoalvelor clearance
- Respiratory epithelial permeability
- Sheep
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
Cite this
Lung clearance of 99mTc-DTPA aerosol in conscious sheep. / Hornof, William J.; O'Callagham, Michael W.; Gunther, Robert A.; Howard, Red; Fisher, Paul; Raabe, Otto; Cross, Carroll E.
In: Respiration Physiology, Vol. 72, No. 3, 1988, p. 375-389.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lung clearance of 99mTc-DTPA aerosol in conscious sheep
AU - Hornof, William J.
AU - O'Callagham, Michael W.
AU - Gunther, Robert A.
AU - Howard, Red
AU - Fisher, Paul
AU - Raabe, Otto
AU - Cross, Carroll E
PY - 1988
Y1 - 1988
N2 - This study was initiated to determine the rate and characteristics of 99Tc-DTPA clearance from the whole lung in a group of 9 sheep. Submicronic aerosol droplets were delivered to unsedated sheep held in sing-like frame. Best fits for clearance to single- and bioexponentials were calculated. The monoexponential T50 for the aerosol clearance was 293 in ± 74 SD. Background correction was found to have a minimal effect (approx. 10%). Bioexponential fitting only marginally improved correlations in the 8 healthy sheep, but in one additional animal with clinical evidence of pneumonia, clearance was faster and biexponential fitting was substantially better. These clearance values in conscious sheep are longer than previous findings mwith 99mTc-DTPA in anesthetized sheep. There appears to be a wide variation of radioaerosol 99mTc-DTPA lung clearances among different species, sheep exhibiting a comparatively prolonged clearance profile.
AB - This study was initiated to determine the rate and characteristics of 99Tc-DTPA clearance from the whole lung in a group of 9 sheep. Submicronic aerosol droplets were delivered to unsedated sheep held in sing-like frame. Best fits for clearance to single- and bioexponentials were calculated. The monoexponential T50 for the aerosol clearance was 293 in ± 74 SD. Background correction was found to have a minimal effect (approx. 10%). Bioexponential fitting only marginally improved correlations in the 8 healthy sheep, but in one additional animal with clinical evidence of pneumonia, clearance was faster and biexponential fitting was substantially better. These clearance values in conscious sheep are longer than previous findings mwith 99mTc-DTPA in anesthetized sheep. There appears to be a wide variation of radioaerosol 99mTc-DTPA lung clearances among different species, sheep exhibiting a comparatively prolonged clearance profile.
KW - Bronchoalvelor clearance
KW - Respiratory epithelial permeability
KW - Sheep
UR - http://www.scopus.com/inward/record.url?scp=0023889541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023889541&partnerID=8YFLogxK
U2 - 10.1016/0034-5687(88)90095-3
DO - 10.1016/0034-5687(88)90095-3
M3 - Article
C2 - 3043605
AN - SCOPUS:0023889541
VL - 72
SP - 375
EP - 389
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 3
ER -