Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study.

S. A. Kieffer, E. F. Binet, D. O. Davis, T. O. Gabrielsen, D. K. Kido, Richard E Latchaw, P. A. Turski, D. D. Shaw

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as "good" or "excellent" in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.

Original languageEnglish (US)
JournalInvestigative Radiology
Volume20
Issue number1 Suppl
StatePublished - Jan 1985
Externally publishedYes

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Iohexol
Metrizamide
Myelography
Multicenter Studies
Prospective Studies
Confusion
Contrast Media
Double-Blind Method
Nausea
Vomiting
Headache
Incidence

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Kieffer, S. A., Binet, E. F., Davis, D. O., Gabrielsen, T. O., Kido, D. K., Latchaw, R. E., ... Shaw, D. D. (1985). Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study. Investigative Radiology, 20(1 Suppl).

Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study. / Kieffer, S. A.; Binet, E. F.; Davis, D. O.; Gabrielsen, T. O.; Kido, D. K.; Latchaw, Richard E; Turski, P. A.; Shaw, D. D.

In: Investigative Radiology, Vol. 20, No. 1 Suppl, 01.1985.

Research output: Contribution to journalArticle

Kieffer, SA, Binet, EF, Davis, DO, Gabrielsen, TO, Kido, DK, Latchaw, RE, Turski, PA & Shaw, DD 1985, 'Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study.', Investigative Radiology, vol. 20, no. 1 Suppl.
Kieffer SA, Binet EF, Davis DO, Gabrielsen TO, Kido DK, Latchaw RE et al. Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study. Investigative Radiology. 1985 Jan;20(1 Suppl).
Kieffer, S. A. ; Binet, E. F. ; Davis, D. O. ; Gabrielsen, T. O. ; Kido, D. K. ; Latchaw, Richard E ; Turski, P. A. ; Shaw, D. D. / Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study. In: Investigative Radiology. 1985 ; Vol. 20, No. 1 Suppl.
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