Abstract
Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as "good" or "excellent" in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.
| Original language | English (US) |
|---|---|
| Journal | Investigative Radiology |
| Volume | 20 |
| Issue number | 1 Suppl |
| State | Published - Jan 1985 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study. / Kieffer, S. A.; Binet, E. F.; Davis, D. O.; Gabrielsen, T. O.; Kido, D. K.; Latchaw, Richard E; Turski, P. A.; Shaw, D. D.
In: Investigative Radiology, Vol. 20, No. 1 Suppl, 01.1985.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study.
AU - Kieffer, S. A.
AU - Binet, E. F.
AU - Davis, D. O.
AU - Gabrielsen, T. O.
AU - Kido, D. K.
AU - Latchaw, Richard E
AU - Turski, P. A.
AU - Shaw, D. D.
PY - 1985/1
Y1 - 1985/1
N2 - Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as "good" or "excellent" in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.
AB - Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as "good" or "excellent" in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.
UR - http://www.scopus.com/inward/record.url?scp=0021906340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021906340&partnerID=8YFLogxK
M3 - Article
C2 - 3882614
AN - SCOPUS:0021906340
VL - 20
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 1 Suppl
ER -