Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study.

S. A. Kieffer; E. F. Binet; D. O. Davis; T. O. Gabrielsen; D. K. Kido; Richard E Latchaw; P. A. Turski; D. D. Shaw

Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study.

S. A. Kieffer, E. F. Binet, D. O. Davis, T. O. Gabrielsen, D. K. Kido, Richard E Latchaw, P. A. Turski, D. D. Shaw

Research output: Contribution to journal › Article › peer-review

Abstract

Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as "good" or "excellent" in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.

Original language	English (US)
Journal	Investigative Radiology
Volume	20
Issue number	1 Suppl
State	Published - Jan 1985
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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Cite this

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title = "Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study.",

abstract = "Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as {"}good{"} or {"}excellent{"} in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.",

author = "Kieffer, {S. A.} and Binet, {E. F.} and Davis, {D. O.} and Gabrielsen, {T. O.} and Kido, {D. K.} and Latchaw, {Richard E} and Turski, {P. A.} and Shaw, {D. D.}",

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T1 - Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study.

AU - Kieffer, S. A.

AU - Binet, E. F.

AU - Davis, D. O.

AU - Gabrielsen, T. O.

AU - Kido, D. K.

AU - Latchaw, Richard E

AU - Turski, P. A.

AU - Shaw, D. D.

PY - 1985/1

Y1 - 1985/1

N2 - Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as "good" or "excellent" in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.

AB - Diagnostic quality and adverse reactions associated with metrizamide and iohexol as contrast agents for lumbar myelography were compared in a prospective randomized double-blind study in 350 patients at seven centers. Both contrast media were administered in comparable volumes at a concentration of 180 mg I/ml. Overall quality of radiographic visualization was graded as "good" or "excellent" in 95% of 175 metrizamide studies and in 98% of 175 iohexol myelograms. Ninety-three patients examined with metrizamide (53%) and 130 patients studied with iohexol (74%) experienced no discomfort during or after myelography. The incidence of postmyelographic headache was 38% with metrizamide and 21% with iohexol. Nausea and vomiting were also more common with metrizamide. Five patients examined with metrizamide (3%) experienced transient confusion and disorientation after lumbar myelography. No such reactions were observed after iohexol myelography.

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