LTP: GluN2B on the go

Lucas Matt, Johannes W Hell

Research output: Contribution to journal › Article

Abstract

LTP, the lasting increase in synaptic transmission following heightened activity, is viewed as the physiological basis of learning. In this issue of The EMBO Journal, Dupuis et al find that certain NMDARs diffuse away upon LTP. Antibodies against the NMDAR from patients with autoimmune synaptic encephalitis prevent this redistribution and LTP. Lateral diffusion of neuronal NMDA receptors is important for synaptic long-term potentiation and may be affected in autoimmune disorders.

Original languageEnglish (US)
Pages (from-to)781-782
Number of pages2
JournalEMBO Journal
Volume33
Issue number8
DOIs
StatePublished - Apr 16 2014

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Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
Synaptic Transmission
Learning
Antibodies
Hashimoto's encephalitis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

LTP : GluN2B on the go. / Matt, Lucas; Hell, Johannes W.

In: EMBO Journal, Vol. 33, No. 8, 16.04.2014, p. 781-782.

Research output: Contribution to journal › Article

Matt, L & Hell, JW 2014, 'LTP: GluN2B on the go', EMBO Journal, vol. 33, no. 8, pp. 781-782. https://doi.org/10.1002/embj.201487958
Matt L, Hell JW. LTP: GluN2B on the go. EMBO Journal. 2014 Apr 16;33(8):781-782. https://doi.org/10.1002/embj.201487958
Matt, Lucas ; Hell, Johannes W. / LTP : GluN2B on the go. In: EMBO Journal. 2014 ; Vol. 33, No. 8. pp. 781-782.
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