LTP: GluN2B on the go

Lucas Matt; Johannes W Hell

doi:10.1002/embj.201487958

LTP: GluN2B on the go

Lucas Matt, Johannes W Hell

Pharmacology

Research output: Contribution to journal › Article

Abstract

LTP, the lasting increase in synaptic transmission following heightened activity, is viewed as the physiological basis of learning. In this issue of The EMBO Journal, Dupuis et al find that certain NMDARs diffuse away upon LTP. Antibodies against the NMDAR from patients with autoimmune synaptic encephalitis prevent this redistribution and LTP. Lateral diffusion of neuronal NMDA receptors is important for synaptic long-term potentiation and may be affected in autoimmune disorders.

Original language	English (US)
Pages (from-to)	781-782
Number of pages	2
Journal	EMBO Journal
Volume	33
Issue number	8
DOIs	https://doi.org/10.1002/embj.201487958
State	Published - Apr 16 2014

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ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Neuroscience(all)

Cite this

Matt, L., & Hell, J. W. (2014). LTP: GluN2B on the go. EMBO Journal, 33(8), 781-782. https://doi.org/10.1002/embj.201487958

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10.1002/embj.201487958