Abstract
LTP, the lasting increase in synaptic transmission following heightened activity, is viewed as the physiological basis of learning. In this issue of The EMBO Journal, Dupuis et al find that certain NMDARs diffuse away upon LTP. Antibodies against the NMDAR from patients with autoimmune synaptic encephalitis prevent this redistribution and LTP. Lateral diffusion of neuronal NMDA receptors is important for synaptic long-term potentiation and may be affected in autoimmune disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 781-782 |
| Number of pages | 2 |
| Journal | EMBO Journal |
| Volume | 33 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 16 2014 |
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Neuroscience(all)