Lp(A)-associated oxidized phospholipids in healthy black and white participants in relation to apo(a) size, age, and family structure

Lars Berglund, Kyoungmi Kim, Wei Zhang, Nishant Prakash, Kevin Truax, Erdembileg Anuurad, Byambaa Enkhmaa

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Lp(a) (lipoprotein(a)) is the major lipoprotein carrier of oxidized phospholipids (OxPL) and this function medi-ates Lp(a) atherogenicity. However, the relationship between OxPL, Lp(a), and genetic and biological characteristics remains poorly understood. We assessed the relationship between Lp(a)-bound OxPL, apolipoprotein(a) (apo(a)) size, age, and family structure in 2 racial groups. METHODS AND RESULTS: Healthy Black and White families were recruited from the general population (age: 6–74 years, n=267). OxPL and Lp(a) levels were assayed enzymatically; apo(a) isoform, LPA allele sizes, and allele-specific Lp(a) levels were de-termined. Lp(a)-OxPL levels did not differ significantly by racial and age groups. Lp(a)-OxPL levels were associated with total plasma Lp(a) in all participants and in race-specific analyses. Further, OxPL levels were significantly associated with allele-specific Lp(a) levels carried by the smaller apo(a) size in all participants (β=0.33, P=0.0003) as well as separately for Black (β=0.50, P=0.0032) and White (β=0.26, P=0.0181) participants. A significant association of OxPL with allele-specific Lp(a) levels for larger apo(a) sizes was seen only in Black participants (β=0.53, P=0.0076). In this group, Lp(a)-OxPL levels were also heritable (h2=0.29, P=0.0235), resulting in a significant interracial difference in heritability between Black and White people (P=0.0352). CONCLUSIONS: Lp(a)-OxPL levels were associated with allele-specific Lp(a) level carried on smaller apo(a) sizes and among Black participants also for larger apo(a) sizes. The heritability estimates for Lp(a)-bound OxPL differed by race.

Original languageEnglish (US)
Article numbere020158
JournalJournal of the American Heart Association
Volume10
Issue number17
DOIs
StatePublished - Sep 1 2021

Keywords

  • Children
  • General population
  • Oxidized lipids
  • Parents
  • Race

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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