Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases

Maureen A. Griffin, William T.N. Culp, Michelle A. Giuffrida, Peter Ellis, Joanne Tuohy, James A. Perry, Allison Gedney, Cassie N. Lux, Milan Milovancev, Mandy L. Wallace, Jonathan Hash, Kyle Mathews, Julius M. Liptak, Laura E. Selmic, Ameet Singh, Carrie A. Palm, Ingrid M. Balsa, Philipp D. Mayhew, Michele A. Steffey, Robert B. RebhunJenna H. Burton, Michael S. Kent

Research output: Contribution to journalArticle

Abstract

Background: Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats. Objectives: To report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance. Animals: One-hundred eighteen client-owned cats with lower urinary tract carcinoma. Methods: Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically. Results: Median age of affected cats was 15 years (range, 5.0-20.8 years) and median duration of clinical signs was 30 days (range, 0-730 days). The trigone was the most common tumor location (32/118; 27.1%) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9%) cats. Metastatic disease was documented in 25 of 118 (21.2%) cats. Median progression-free survival and survival time for all cats were 113 days (95% confidence interval [CI], 69-153) and 155 days (95% CI, 110-222), respectively. Survival increased significantly (P <.001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95% CI, 0.17-0.87) and treatment with nonsteroidal anti-inflammatory drugs (HR, 0.55; 95% CI, 0.33-0.93) were significantly associated with longer survival times. Conclusions and Clinical Importance: The results support treatment using partial cystectomy and NSAIDs in cats with TCC.

Original languageEnglish (US)
JournalJournal of Veterinary Internal Medicine
DOIs
StateAccepted/In press - Jan 1 2019

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Transitional Cell Carcinoma
urinary tract
Urinary Tract
carcinoma
Cats
cats
Cystectomy
confidence interval
cells
Confidence Intervals
nonsteroidal anti-inflammatory agents
cystoscopy
Cat Diseases
cat diseases
Cystoscopy
Non-Steroidal Anti-Inflammatory Agents
Disease-Free Survival
Medical Records
Anti-Inflammatory Agents
Carcinoma

Keywords

  • bladder
  • cat
  • cystectomy
  • neoplasia
  • urethra

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Lower urinary tract transitional cell carcinoma in cats : Clinical findings, treatments, and outcomes in 118 cases. / Griffin, Maureen A.; Culp, William T.N.; Giuffrida, Michelle A.; Ellis, Peter; Tuohy, Joanne; Perry, James A.; Gedney, Allison; Lux, Cassie N.; Milovancev, Milan; Wallace, Mandy L.; Hash, Jonathan; Mathews, Kyle; Liptak, Julius M.; Selmic, Laura E.; Singh, Ameet; Palm, Carrie A.; Balsa, Ingrid M.; Mayhew, Philipp D.; Steffey, Michele A.; Rebhun, Robert B.; Burton, Jenna H.; Kent, Michael S.

In: Journal of Veterinary Internal Medicine, 01.01.2019.

Research output: Contribution to journalArticle

Griffin, Maureen A. ; Culp, William T.N. ; Giuffrida, Michelle A. ; Ellis, Peter ; Tuohy, Joanne ; Perry, James A. ; Gedney, Allison ; Lux, Cassie N. ; Milovancev, Milan ; Wallace, Mandy L. ; Hash, Jonathan ; Mathews, Kyle ; Liptak, Julius M. ; Selmic, Laura E. ; Singh, Ameet ; Palm, Carrie A. ; Balsa, Ingrid M. ; Mayhew, Philipp D. ; Steffey, Michele A. ; Rebhun, Robert B. ; Burton, Jenna H. ; Kent, Michael S. / Lower urinary tract transitional cell carcinoma in cats : Clinical findings, treatments, and outcomes in 118 cases. In: Journal of Veterinary Internal Medicine. 2019.
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abstract = "Background: Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats. Objectives: To report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance. Animals: One-hundred eighteen client-owned cats with lower urinary tract carcinoma. Methods: Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically. Results: Median age of affected cats was 15 years (range, 5.0-20.8 years) and median duration of clinical signs was 30 days (range, 0-730 days). The trigone was the most common tumor location (32/118; 27.1{\%}) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9{\%}) cats. Metastatic disease was documented in 25 of 118 (21.2{\%}) cats. Median progression-free survival and survival time for all cats were 113 days (95{\%} confidence interval [CI], 69-153) and 155 days (95{\%} CI, 110-222), respectively. Survival increased significantly (P <.001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95{\%} CI, 0.17-0.87) and treatment with nonsteroidal anti-inflammatory drugs (HR, 0.55; 95{\%} CI, 0.33-0.93) were significantly associated with longer survival times. Conclusions and Clinical Importance: The results support treatment using partial cystectomy and NSAIDs in cats with TCC.",
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T2 - Clinical findings, treatments, and outcomes in 118 cases

AU - Griffin, Maureen A.

AU - Culp, William T.N.

AU - Giuffrida, Michelle A.

AU - Ellis, Peter

AU - Tuohy, Joanne

AU - Perry, James A.

AU - Gedney, Allison

AU - Lux, Cassie N.

AU - Milovancev, Milan

AU - Wallace, Mandy L.

AU - Hash, Jonathan

AU - Mathews, Kyle

AU - Liptak, Julius M.

AU - Selmic, Laura E.

AU - Singh, Ameet

AU - Palm, Carrie A.

AU - Balsa, Ingrid M.

AU - Mayhew, Philipp D.

AU - Steffey, Michele A.

AU - Rebhun, Robert B.

AU - Burton, Jenna H.

AU - Kent, Michael S.

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N2 - Background: Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats. Objectives: To report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance. Animals: One-hundred eighteen client-owned cats with lower urinary tract carcinoma. Methods: Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically. Results: Median age of affected cats was 15 years (range, 5.0-20.8 years) and median duration of clinical signs was 30 days (range, 0-730 days). The trigone was the most common tumor location (32/118; 27.1%) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9%) cats. Metastatic disease was documented in 25 of 118 (21.2%) cats. Median progression-free survival and survival time for all cats were 113 days (95% confidence interval [CI], 69-153) and 155 days (95% CI, 110-222), respectively. Survival increased significantly (P <.001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95% CI, 0.17-0.87) and treatment with nonsteroidal anti-inflammatory drugs (HR, 0.55; 95% CI, 0.33-0.93) were significantly associated with longer survival times. Conclusions and Clinical Importance: The results support treatment using partial cystectomy and NSAIDs in cats with TCC.

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