Abstract
Objective: To determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance. Design: Longitudinal cohort study. Setting: Community-based sample from 4 urban areas. Participants: Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630). Interventions: Not applicable. Main Outcome Measures: Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical function was defined as the minimal clinically important difference for worsening self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale score, 20-m walk time, and repeated chair stand time over 36 months. Results: Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an odds ratio (OR) of .68 (95% confidence interval [CI], .51-.92) after adjustment for age, sex, body mass index, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an adjusted OR of .57 (95% CI, .38-.86). This decreased risk did not reach statistical significance in men (OR, 0.81; 95% CI, 0.52-1.27). No statistically significant associations were detected between baseline RFD and walk or chair stand times. Conclusions: Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance.
| Original language | English (US) |
|---|---|
| Journal | Archives of Physical Medicine and Rehabilitation |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Knee
- Muscle Strength
- Osteoarthritis
- Quadriceps muscle
- Rehabilitation
- Sports Medicine
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Rehabilitation
Cite this
Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis : 36-Month Follow-Up Data From the Osteoarthritis Initiative. / Hu, Bo; Skou, Søren Thorgaard; Wise, Barton L; Williams, Glenn N.; Nevitt, Michael C.; Segal, Neil A.
In: Archives of Physical Medicine and Rehabilitation, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis
T2 - 36-Month Follow-Up Data From the Osteoarthritis Initiative
AU - Hu, Bo
AU - Skou, Søren Thorgaard
AU - Wise, Barton L
AU - Williams, Glenn N.
AU - Nevitt, Michael C.
AU - Segal, Neil A.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objective: To determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance. Design: Longitudinal cohort study. Setting: Community-based sample from 4 urban areas. Participants: Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630). Interventions: Not applicable. Main Outcome Measures: Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical function was defined as the minimal clinically important difference for worsening self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale score, 20-m walk time, and repeated chair stand time over 36 months. Results: Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an odds ratio (OR) of .68 (95% confidence interval [CI], .51-.92) after adjustment for age, sex, body mass index, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an adjusted OR of .57 (95% CI, .38-.86). This decreased risk did not reach statistical significance in men (OR, 0.81; 95% CI, 0.52-1.27). No statistically significant associations were detected between baseline RFD and walk or chair stand times. Conclusions: Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance.
AB - Objective: To determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance. Design: Longitudinal cohort study. Setting: Community-based sample from 4 urban areas. Participants: Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630). Interventions: Not applicable. Main Outcome Measures: Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical function was defined as the minimal clinically important difference for worsening self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale score, 20-m walk time, and repeated chair stand time over 36 months. Results: Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an odds ratio (OR) of .68 (95% confidence interval [CI], .51-.92) after adjustment for age, sex, body mass index, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an adjusted OR of .57 (95% CI, .38-.86). This decreased risk did not reach statistical significance in men (OR, 0.81; 95% CI, 0.52-1.27). No statistically significant associations were detected between baseline RFD and walk or chair stand times. Conclusions: Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance.
KW - Knee
KW - Muscle Strength
KW - Osteoarthritis
KW - Quadriceps muscle
KW - Rehabilitation
KW - Sports Medicine
UR - http://www.scopus.com/inward/record.url?scp=85043230160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043230160&partnerID=8YFLogxK
U2 - 10.1016/j.apmr.2017.12.027
DO - 10.1016/j.apmr.2017.12.027
M3 - Article
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
ER -