Low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair

Kimberly S. Balay, Keli M. Hawthorne, Penni D. Hicks, Zhensheng Chen, Ian J. Griffin, Steven A. Abrams

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

There is very little data regarding trace mineral nutrition in infants with small intestinal ostomies. Here we evaluated 14 infants with jejunal or ileal ostomies to measure their zinc absorption and retention and biochemical zinc and copper status. Zinc absorption was measured using a dual-tracer stable isotope technique at two different time points when possible. The first study was conducted when the subject was receiving maximal tolerated feeds enterally while the ostomy remained in place. A second study was performed as soon as feasible after full feeds were achieved after intestinal repair. We found biochemical evidence of deficiencies of both zinc and copper in infants with small intestinal ostomies at both time points. Fractional zinc absorption with an ostomy in place was 10.9% ± 5.3%. After reanastamosis, fractional zinc absorption was 9.4% ± 5.7%. Net zinc balance was negative prior to reanastamosis. In conclusion, our data demonstrate that infants with a jejunostomy or ileostomy are at high risk for zinc and copper deficiency before and after intestinal reanastamosis. Additional supplementation, especially of zinc, should be considered during this time period.

Original languageEnglish (US)
Pages (from-to)1273-1281
Number of pages9
JournalNutrients
Volume4
Issue number9
DOIs
StatePublished - Sep 2012

Fingerprint

Jejunostomy
Ileostomy
Zinc
Ostomy
zinc
Copper
copper
Trace Elements
Isotopes
stable isotopes
trace elements
tracer techniques

Keywords

  • Copper
  • Ileostomy
  • Jejunostomy
  • Nutrient absorption
  • Ostomy
  • Zinc

ASJC Scopus subject areas

  • Food Science

Cite this

Balay, K. S., Hawthorne, K. M., Hicks, P. D., Chen, Z., Griffin, I. J., & Abrams, S. A. (2012). Low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair. Nutrients, 4(9), 1273-1281. https://doi.org/10.3390/nu4091273

Low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair. / Balay, Kimberly S.; Hawthorne, Keli M.; Hicks, Penni D.; Chen, Zhensheng; Griffin, Ian J.; Abrams, Steven A.

In: Nutrients, Vol. 4, No. 9, 09.2012, p. 1273-1281.

Research output: Contribution to journalArticle

Balay, KS, Hawthorne, KM, Hicks, PD, Chen, Z, Griffin, IJ & Abrams, SA 2012, 'Low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair', Nutrients, vol. 4, no. 9, pp. 1273-1281. https://doi.org/10.3390/nu4091273
Balay, Kimberly S. ; Hawthorne, Keli M. ; Hicks, Penni D. ; Chen, Zhensheng ; Griffin, Ian J. ; Abrams, Steven A. / Low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair. In: Nutrients. 2012 ; Vol. 4, No. 9. pp. 1273-1281.
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