Low vitamin d levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications

Sridevi Devaraj, Jung Mi Yun, Catherine R. Duncan-Staley, Ishwarlal Jialal

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Epidemiologic studies link vitamin D deficiency to onset of type 1 diabetes mellitus (T1DM). T1DM exhibits increased inflammation, which is pronounced with microvascular complications (T1DM-MV). However, there are a paucity of data on vitamin D in T1DM-MV in relation to biomarkers of inflammation, and this formed the aim of the study. Healthy control subjects (n = 36), patients with T1DM (n = 24), and patients with T1DM-MV (n =26) were recruited. Serum vitamin D levels, monocyte tolllike receptor (TLR) 2 and TLR4 expression and nuclear factor-κB (NFκB) activity were assessed. Patients with T1DM and T1DM-MV were significantly vitamin D deficient compared with control subjects (P <.01). There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NF κB activity, and TLR4 expression (P <.05). Preincubation with vitamin D significantly decreased lipopolysaccharide-activated TLR4 expression and cytokine levels in monocytes (P <.05). Low vitamin D levels may contribute to increased inflammation in T1DM. Future studies will elucidate the immunomodulatory effects of vitamin D in decreasing vascular risk in this population.

Original languageEnglish (US)
Pages (from-to)429-433
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume135
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • Diabetes
  • Inflammation
  • Vitamin D

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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