Low vitamin d levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications

Sridevi Devaraj, Jung Mi Yun, Catherine R. Duncan-Staley, Ishwarlal Jialal

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Epidemiologic studies link vitamin D deficiency to onset of type 1 diabetes mellitus (T1DM). T1DM exhibits increased inflammation, which is pronounced with microvascular complications (T1DM-MV). However, there are a paucity of data on vitamin D in T1DM-MV in relation to biomarkers of inflammation, and this formed the aim of the study. Healthy control subjects (n = 36), patients with T1DM (n = 24), and patients with T1DM-MV (n =26) were recruited. Serum vitamin D levels, monocyte tolllike receptor (TLR) 2 and TLR4 expression and nuclear factor-κB (NFκB) activity were assessed. Patients with T1DM and T1DM-MV were significantly vitamin D deficient compared with control subjects (P <.01). There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NF κB activity, and TLR4 expression (P <.05). Preincubation with vitamin D significantly decreased lipopolysaccharide-activated TLR4 expression and cytokine levels in monocytes (P <.05). Low vitamin D levels may contribute to increased inflammation in T1DM. Future studies will elucidate the immunomodulatory effects of vitamin D in decreasing vascular risk in this population.

Original languageEnglish (US)
Pages (from-to)429-433
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume135
Issue number3
DOIs
StatePublished - Mar 2011

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Type 1 Diabetes Mellitus
Vitamins
Vitamin D
Inflammation
Monocytes
Toll-Like Receptor 4
Vitamin D Deficiency
Diabetes Complications
C-Reactive Protein
Blood Vessels
Lipopolysaccharides
Epidemiologic Studies
Healthy Volunteers
Biomarkers
Cytokines
Serum
Population

Keywords

  • Diabetes
  • Inflammation
  • Vitamin D

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Low vitamin d levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications. / Devaraj, Sridevi; Yun, Jung Mi; Duncan-Staley, Catherine R.; Jialal, Ishwarlal.

In: American Journal of Clinical Pathology, Vol. 135, No. 3, 03.2011, p. 429-433.

Research output: Contribution to journalArticle

Devaraj, Sridevi ; Yun, Jung Mi ; Duncan-Staley, Catherine R. ; Jialal, Ishwarlal. / Low vitamin d levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications. In: American Journal of Clinical Pathology. 2011 ; Vol. 135, No. 3. pp. 429-433.
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