Low sociability in BTBR T+tf/J mice is independent of partner strain

Mu Yang, Danielle N. Abrams, James Y. Zhang, Michael D. Weber, Adam M. Katz, Andrew M. Clarke, Jill L Silverman, Jacqueline Crawley

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Inbred mouse strains differ greatly in social behaviors, making them a valuable resource to study genetic and non-genetic mechanisms underlying social deficits relevant to autism spectrum disorders. A hallmark symptom of autism is a lack of ability to understand other people's thoughts and intentions, which leads to impairments in adjusting behaviors in response to ever-changing social situations in daily life. We compared the ability of BTBR T + tf/J (BTBR), a strain with low sociability, and C57BL/6J (B6), a strain with high sociability, for their abilities to modulate responses to social cues from different partners in the reciprocal social interaction test. Results indicate that BTBR exhibited low sociability toward different partners and displayed minimal ability to modify behaviors toward different partners. In contrast, B6 showed high sociability toward different partners and was able to modify social behaviors toward different partners. Consistent results were found in two independent cohorts of different ages, and in both sexes. In the three-chambered test, high sociability in B6 and low sociability in BTBR were independent of strain of the novel mouse. Since social deficits in BTBR could potentially be caused by physical disabilities in detecting social olfactory cues, or in cognitive abilities, we tested BTBR and B6 mice on measures of olfaction and cognition. BTBR mice displayed more sniffing of social odors emitted by soiled bedding than of an odorless novel object, but failed to show a preference for a live novel mouse over a novel object. On olfactory habituation/dishabituation to a sequence of odors, BTBR displayed discrimination abilities across three non-social and two social odors. However, as compared to B6, BTBR displayed less sniff time for both non-social and social odors, and no significant dishabituation between cage odors from two different novel mouse strains, findings that will be important to investigate further. BTBR was generally normal in spatial acquisition on the Morris water maze test, but showed deficits in reversal learning. Time spent freezing on contextual and cued fear conditioning was lower in BTBR than in B6. Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism.

Original languageEnglish (US)
Pages (from-to)649-662
Number of pages14
JournalPhysiology and Behavior
Volume107
Issue number5
DOIs
StatePublished - Dec 5 2012
Externally publishedYes

Fingerprint

Aptitude
Autistic Disorder
Social Behavior
Cognition
Cues
Reversal Learning
Inbred Strains Mice
Smell
Interpersonal Relations
Sociability
Mouse
Freezing
Fear
Odorants
Water
Autism

Keywords

  • Autism
  • BTBR T+tf/J
  • Inbred strains
  • Mouse models
  • Mouse social behaviors
  • Olfactory habituation/dishabituation
  • Reciprocal social interaction
  • Repetitive behaviors
  • Social partner
  • Three-chambered social approach task

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Philosophy

Cite this

Yang, M., Abrams, D. N., Zhang, J. Y., Weber, M. D., Katz, A. M., Clarke, A. M., ... Crawley, J. (2012). Low sociability in BTBR T+tf/J mice is independent of partner strain. Physiology and Behavior, 107(5), 649-662. https://doi.org/10.1016/j.physbeh.2011.12.025

Low sociability in BTBR T+tf/J mice is independent of partner strain. / Yang, Mu; Abrams, Danielle N.; Zhang, James Y.; Weber, Michael D.; Katz, Adam M.; Clarke, Andrew M.; Silverman, Jill L; Crawley, Jacqueline.

In: Physiology and Behavior, Vol. 107, No. 5, 05.12.2012, p. 649-662.

Research output: Contribution to journalArticle

Yang M, Abrams DN, Zhang JY, Weber MD, Katz AM, Clarke AM et al. Low sociability in BTBR T+tf/J mice is independent of partner strain. Physiology and Behavior. 2012 Dec 5;107(5):649-662. https://doi.org/10.1016/j.physbeh.2011.12.025
Yang, Mu ; Abrams, Danielle N. ; Zhang, James Y. ; Weber, Michael D. ; Katz, Adam M. ; Clarke, Andrew M. ; Silverman, Jill L ; Crawley, Jacqueline. / Low sociability in BTBR T+tf/J mice is independent of partner strain. In: Physiology and Behavior. 2012 ; Vol. 107, No. 5. pp. 649-662.
@article{0d6fa4b77e344cf2893aaecdb1cf3fab,
title = "Low sociability in BTBR T+tf/J mice is independent of partner strain",
abstract = "Inbred mouse strains differ greatly in social behaviors, making them a valuable resource to study genetic and non-genetic mechanisms underlying social deficits relevant to autism spectrum disorders. A hallmark symptom of autism is a lack of ability to understand other people's thoughts and intentions, which leads to impairments in adjusting behaviors in response to ever-changing social situations in daily life. We compared the ability of BTBR T + tf/J (BTBR), a strain with low sociability, and C57BL/6J (B6), a strain with high sociability, for their abilities to modulate responses to social cues from different partners in the reciprocal social interaction test. Results indicate that BTBR exhibited low sociability toward different partners and displayed minimal ability to modify behaviors toward different partners. In contrast, B6 showed high sociability toward different partners and was able to modify social behaviors toward different partners. Consistent results were found in two independent cohorts of different ages, and in both sexes. In the three-chambered test, high sociability in B6 and low sociability in BTBR were independent of strain of the novel mouse. Since social deficits in BTBR could potentially be caused by physical disabilities in detecting social olfactory cues, or in cognitive abilities, we tested BTBR and B6 mice on measures of olfaction and cognition. BTBR mice displayed more sniffing of social odors emitted by soiled bedding than of an odorless novel object, but failed to show a preference for a live novel mouse over a novel object. On olfactory habituation/dishabituation to a sequence of odors, BTBR displayed discrimination abilities across three non-social and two social odors. However, as compared to B6, BTBR displayed less sniff time for both non-social and social odors, and no significant dishabituation between cage odors from two different novel mouse strains, findings that will be important to investigate further. BTBR was generally normal in spatial acquisition on the Morris water maze test, but showed deficits in reversal learning. Time spent freezing on contextual and cued fear conditioning was lower in BTBR than in B6. Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism.",
keywords = "Autism, BTBR T+tf/J, Inbred strains, Mouse models, Mouse social behaviors, Olfactory habituation/dishabituation, Reciprocal social interaction, Repetitive behaviors, Social partner, Three-chambered social approach task",
author = "Mu Yang and Abrams, {Danielle N.} and Zhang, {James Y.} and Weber, {Michael D.} and Katz, {Adam M.} and Clarke, {Andrew M.} and Silverman, {Jill L} and Jacqueline Crawley",
year = "2012",
month = "12",
day = "5",
doi = "10.1016/j.physbeh.2011.12.025",
language = "English (US)",
volume = "107",
pages = "649--662",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Low sociability in BTBR T+tf/J mice is independent of partner strain

AU - Yang, Mu

AU - Abrams, Danielle N.

AU - Zhang, James Y.

AU - Weber, Michael D.

AU - Katz, Adam M.

AU - Clarke, Andrew M.

AU - Silverman, Jill L

AU - Crawley, Jacqueline

PY - 2012/12/5

Y1 - 2012/12/5

N2 - Inbred mouse strains differ greatly in social behaviors, making them a valuable resource to study genetic and non-genetic mechanisms underlying social deficits relevant to autism spectrum disorders. A hallmark symptom of autism is a lack of ability to understand other people's thoughts and intentions, which leads to impairments in adjusting behaviors in response to ever-changing social situations in daily life. We compared the ability of BTBR T + tf/J (BTBR), a strain with low sociability, and C57BL/6J (B6), a strain with high sociability, for their abilities to modulate responses to social cues from different partners in the reciprocal social interaction test. Results indicate that BTBR exhibited low sociability toward different partners and displayed minimal ability to modify behaviors toward different partners. In contrast, B6 showed high sociability toward different partners and was able to modify social behaviors toward different partners. Consistent results were found in two independent cohorts of different ages, and in both sexes. In the three-chambered test, high sociability in B6 and low sociability in BTBR were independent of strain of the novel mouse. Since social deficits in BTBR could potentially be caused by physical disabilities in detecting social olfactory cues, or in cognitive abilities, we tested BTBR and B6 mice on measures of olfaction and cognition. BTBR mice displayed more sniffing of social odors emitted by soiled bedding than of an odorless novel object, but failed to show a preference for a live novel mouse over a novel object. On olfactory habituation/dishabituation to a sequence of odors, BTBR displayed discrimination abilities across three non-social and two social odors. However, as compared to B6, BTBR displayed less sniff time for both non-social and social odors, and no significant dishabituation between cage odors from two different novel mouse strains, findings that will be important to investigate further. BTBR was generally normal in spatial acquisition on the Morris water maze test, but showed deficits in reversal learning. Time spent freezing on contextual and cued fear conditioning was lower in BTBR than in B6. Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism.

AB - Inbred mouse strains differ greatly in social behaviors, making them a valuable resource to study genetic and non-genetic mechanisms underlying social deficits relevant to autism spectrum disorders. A hallmark symptom of autism is a lack of ability to understand other people's thoughts and intentions, which leads to impairments in adjusting behaviors in response to ever-changing social situations in daily life. We compared the ability of BTBR T + tf/J (BTBR), a strain with low sociability, and C57BL/6J (B6), a strain with high sociability, for their abilities to modulate responses to social cues from different partners in the reciprocal social interaction test. Results indicate that BTBR exhibited low sociability toward different partners and displayed minimal ability to modify behaviors toward different partners. In contrast, B6 showed high sociability toward different partners and was able to modify social behaviors toward different partners. Consistent results were found in two independent cohorts of different ages, and in both sexes. In the three-chambered test, high sociability in B6 and low sociability in BTBR were independent of strain of the novel mouse. Since social deficits in BTBR could potentially be caused by physical disabilities in detecting social olfactory cues, or in cognitive abilities, we tested BTBR and B6 mice on measures of olfaction and cognition. BTBR mice displayed more sniffing of social odors emitted by soiled bedding than of an odorless novel object, but failed to show a preference for a live novel mouse over a novel object. On olfactory habituation/dishabituation to a sequence of odors, BTBR displayed discrimination abilities across three non-social and two social odors. However, as compared to B6, BTBR displayed less sniff time for both non-social and social odors, and no significant dishabituation between cage odors from two different novel mouse strains, findings that will be important to investigate further. BTBR was generally normal in spatial acquisition on the Morris water maze test, but showed deficits in reversal learning. Time spent freezing on contextual and cued fear conditioning was lower in BTBR than in B6. Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism.

KW - Autism

KW - BTBR T+tf/J

KW - Inbred strains

KW - Mouse models

KW - Mouse social behaviors

KW - Olfactory habituation/dishabituation

KW - Reciprocal social interaction

KW - Repetitive behaviors

KW - Social partner

KW - Three-chambered social approach task

UR - http://www.scopus.com/inward/record.url?scp=84866352950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866352950&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2011.12.025

DO - 10.1016/j.physbeh.2011.12.025

M3 - Article

C2 - 22245067

AN - SCOPUS:84866352950

VL - 107

SP - 649

EP - 662

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 5

ER -