Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates

Andrew A. Butler, Jinsong Zhang, Candice A. Price, Joseph R. Stevens, James L. Graham, Kimber Stanhope, Sarah King, Ronald M. Krauss, Andrew A. Bremer, Peter J Havel

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin's roles in human metabolism are unclear. In silico expression profiling in a nonhuman primate diurnal transcriptome atlas (GSE98965) revealed a dynamic and diurnal pattern of ENHO expression. ENHO expression is abundant in brain, including ventromedial and lateral hypothalamic nuclei regulating appetite and autonomic function. Lower ENHO expression is present in liver, lung, kidney, ileum, and some endocrine glands. Hepatic ENHO expression associates with genes involved in glucose and lipid metabolism. Unsupervised hierarchical clustering identified 426 genes co-regulated with ENHO in liver, ileum, kidney medulla, and lung. Gene Ontology analysis of this cluster revealed enrichment for epigenetic silencing by histone H3K27 trimethylation and biological processes related to neural function. Dietary intervention experiments with 59 adult male rhesus macaques indicated low plasma adropin concentrations were positively correlated with fasting glucose, plasma leptin, and apolipoproteinC3(APOC3) concentrations. During consumption of a high-sugar (fructose) diet, which induced 10% weight gain, animals with low adropin had larger increases of plasma leptin and more severe hyperglycemia. Declining adropin concentrations were correlated with increases of plasma APOC3andtriglycerides. In summary, peripheral ENHO expression associates with pathways related to epigenetic and neural functions, and carbohydrate and lipid metabolism, suggesting co-regulation in nonhuman primates. Low circulating adropin predicts increased weight gain and metabolic dysregulation during consumption of a high-sugar diet.

Original languageEnglish (US)
Pages (from-to)9706-9719
Number of pages14
JournalJournal of Biological Chemistry
Volume294
Issue number25
DOIs
StatePublished - Jan 1 2019

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Nutrition
Sugars
Primates
Weight Gain
Homeostasis
Genes
Diet
Plasmas
Leptin
Metabolism
Glucose
Liver
Lipid Metabolism
Peptide Hormones
Ileum
Epigenomics
Fructose
Cluster Analysis
Histones
Ontology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. / Butler, Andrew A.; Zhang, Jinsong; Price, Candice A.; Stevens, Joseph R.; Graham, James L.; Stanhope, Kimber; King, Sarah; Krauss, Ronald M.; Bremer, Andrew A.; Havel, Peter J.

In: Journal of Biological Chemistry, Vol. 294, No. 25, 01.01.2019, p. 9706-9719.

Research output: Contribution to journalReview article

Butler, Andrew A. ; Zhang, Jinsong ; Price, Candice A. ; Stevens, Joseph R. ; Graham, James L. ; Stanhope, Kimber ; King, Sarah ; Krauss, Ronald M. ; Bremer, Andrew A. ; Havel, Peter J. / Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. In: Journal of Biological Chemistry. 2019 ; Vol. 294, No. 25. pp. 9706-9719.
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abstract = "Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin's roles in human metabolism are unclear. In silico expression profiling in a nonhuman primate diurnal transcriptome atlas (GSE98965) revealed a dynamic and diurnal pattern of ENHO expression. ENHO expression is abundant in brain, including ventromedial and lateral hypothalamic nuclei regulating appetite and autonomic function. Lower ENHO expression is present in liver, lung, kidney, ileum, and some endocrine glands. Hepatic ENHO expression associates with genes involved in glucose and lipid metabolism. Unsupervised hierarchical clustering identified 426 genes co-regulated with ENHO in liver, ileum, kidney medulla, and lung. Gene Ontology analysis of this cluster revealed enrichment for epigenetic silencing by histone H3K27 trimethylation and biological processes related to neural function. Dietary intervention experiments with 59 adult male rhesus macaques indicated low plasma adropin concentrations were positively correlated with fasting glucose, plasma leptin, and apolipoproteinC3(APOC3) concentrations. During consumption of a high-sugar (fructose) diet, which induced 10{\%} weight gain, animals with low adropin had larger increases of plasma leptin and more severe hyperglycemia. Declining adropin concentrations were correlated with increases of plasma APOC3andtriglycerides. In summary, peripheral ENHO expression associates with pathways related to epigenetic and neural functions, and carbohydrate and lipid metabolism, suggesting co-regulation in nonhuman primates. Low circulating adropin predicts increased weight gain and metabolic dysregulation during consumption of a high-sugar diet.",
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AU - Stevens, Joseph R.

AU - Graham, James L.

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