Low heterozygosity is associated with vector-borne disease in crows

Andrea K. Townsend, Conor C. Taff, Sarah S. Wheeler, Allison M. Weis, Mitch G. Hinton, Melissa L. Jones, Ryane M. Logsdon, William Reisen, David Freund, Ravinder N.M. Sehgal, Mojan Saberi, Young Ha Suh, Jacqueline Hurd, Walter M Boyce

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Infectious diseases can have devastating impacts on wildlife populations and are of particular concern for small, inbred populations. Identifying specific pathogens that are linked to morbidity and mortality in inbred individuals is a priority for the conservation of small populations, but opportunities to examine them in the wild are rare. Here, we examined the relationship between heterozygosity and infectious disease in American crows (Corvus brachyrhynchos), a species that engages in close inbreeding, focusing on three pathogens common in Davis, California, USA: West Nile virus (WNV), Plasmodium spp. (avian malaria), and Campylobacter jejuni. We found that low heterozygosity at a panel of 33 microsatellite loci was associated with two vector-borne infectious diseases (WNV and avian malaria), but not with infection by the bacterial gut pathogen C. jejuni. Reasons for this association with vector-borne pathogens are unclear, but might include behavioral factors and immunological differences associated with inbreeding. Overall, these data are consistent with the idea that inbred individuals may be more susceptible to both novel and endemic vector-borne pathogens, underscoring the importance of protecting genetic diversity within populations and buffering small populations against infectious diseases.

Original languageEnglish (US)
Article numbere02407
JournalEcosphere
Volume9
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

vector-borne diseases
crows
heterozygosity
infectious disease
pathogen
infectious diseases
pathogens
Corvus brachyrhynchos
avian malaria
West Nile virus
malaria
inbreeding
Campylobacter jejuni
Plasmodium
morbidity
buffering
wildlife
digestive system
microsatellite repeats
mortality

Keywords

  • Campylobacter jejuni
  • Corvus brachyrhynchos
  • emerging infectious disease
  • endemic disease
  • heterozygosity–fitness correlations
  • inbreeding
  • inbreeding depression
  • Plasmodium
  • vector-borne disease
  • West Nile virus

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

Townsend, A. K., Taff, C. C., Wheeler, S. S., Weis, A. M., Hinton, M. G., Jones, M. L., ... Boyce, W. M. (2018). Low heterozygosity is associated with vector-borne disease in crows. Ecosphere, 9(10), [e02407]. https://doi.org/10.1002/ecs2.2407

Low heterozygosity is associated with vector-borne disease in crows. / Townsend, Andrea K.; Taff, Conor C.; Wheeler, Sarah S.; Weis, Allison M.; Hinton, Mitch G.; Jones, Melissa L.; Logsdon, Ryane M.; Reisen, William; Freund, David; Sehgal, Ravinder N.M.; Saberi, Mojan; Suh, Young Ha; Hurd, Jacqueline; Boyce, Walter M.

In: Ecosphere, Vol. 9, No. 10, e02407, 01.10.2018.

Research output: Contribution to journalArticle

Townsend, AK, Taff, CC, Wheeler, SS, Weis, AM, Hinton, MG, Jones, ML, Logsdon, RM, Reisen, W, Freund, D, Sehgal, RNM, Saberi, M, Suh, YH, Hurd, J & Boyce, WM 2018, 'Low heterozygosity is associated with vector-borne disease in crows', Ecosphere, vol. 9, no. 10, e02407. https://doi.org/10.1002/ecs2.2407
Townsend AK, Taff CC, Wheeler SS, Weis AM, Hinton MG, Jones ML et al. Low heterozygosity is associated with vector-borne disease in crows. Ecosphere. 2018 Oct 1;9(10). e02407. https://doi.org/10.1002/ecs2.2407
Townsend, Andrea K. ; Taff, Conor C. ; Wheeler, Sarah S. ; Weis, Allison M. ; Hinton, Mitch G. ; Jones, Melissa L. ; Logsdon, Ryane M. ; Reisen, William ; Freund, David ; Sehgal, Ravinder N.M. ; Saberi, Mojan ; Suh, Young Ha ; Hurd, Jacqueline ; Boyce, Walter M. / Low heterozygosity is associated with vector-borne disease in crows. In: Ecosphere. 2018 ; Vol. 9, No. 10.
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