Low doses of muscimol produce anticonflict actions in the lateral septum of the rat

RC Drugan, P. Skolnick, SM Paul, Jacqueline Crawley

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Muscimol microinjected into the lateral septum of the rat produced a dose dependent increase in punished responding over the dose range of 100 pg-5 ng. The higher doses used (10 ng and 1 μg) produced sedation and ataxia, markedly reducing the number of approaches to the water spout. This steep, biphasic dose response curve for the anticonflict actions of muscimol may explain contradictory findings in the literature concerning GABAergic involvement in the anxiolytic actions of benzodiazepines. The low dose of muscimol needed to produce a significant anticonflict effect in the lateral septum suggests that this nucleus may be a critical site in anxiety-related behaviors.

Original languageEnglish (US)
Pages (from-to)203-205
Number of pages3
JournalNeuropharmacology
Volume25
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Muscimol
Septal Nuclei
Anti-Anxiety Agents
Ataxia
Benzodiazepines
Anxiety
Water

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Low doses of muscimol produce anticonflict actions in the lateral septum of the rat. / Drugan, RC; Skolnick, P.; Paul, SM; Crawley, Jacqueline.

In: Neuropharmacology, Vol. 25, No. 2, 1986, p. 203-205.

Research output: Contribution to journalArticle

Drugan, RC ; Skolnick, P. ; Paul, SM ; Crawley, Jacqueline. / Low doses of muscimol produce anticonflict actions in the lateral septum of the rat. In: Neuropharmacology. 1986 ; Vol. 25, No. 2. pp. 203-205.
@article{e40d7f896ca944dcba23bdeec247a450,
title = "Low doses of muscimol produce anticonflict actions in the lateral septum of the rat",
abstract = "Muscimol microinjected into the lateral septum of the rat produced a dose dependent increase in punished responding over the dose range of 100 pg-5 ng. The higher doses used (10 ng and 1 μg) produced sedation and ataxia, markedly reducing the number of approaches to the water spout. This steep, biphasic dose response curve for the anticonflict actions of muscimol may explain contradictory findings in the literature concerning GABAergic involvement in the anxiolytic actions of benzodiazepines. The low dose of muscimol needed to produce a significant anticonflict effect in the lateral septum suggests that this nucleus may be a critical site in anxiety-related behaviors.",
author = "RC Drugan and P. Skolnick and SM Paul and Jacqueline Crawley",
year = "1986",
doi = "10.1016/0028-3908(86)90042-0",
language = "English (US)",
volume = "25",
pages = "203--205",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Low doses of muscimol produce anticonflict actions in the lateral septum of the rat

AU - Drugan, RC

AU - Skolnick, P.

AU - Paul, SM

AU - Crawley, Jacqueline

PY - 1986

Y1 - 1986

N2 - Muscimol microinjected into the lateral septum of the rat produced a dose dependent increase in punished responding over the dose range of 100 pg-5 ng. The higher doses used (10 ng and 1 μg) produced sedation and ataxia, markedly reducing the number of approaches to the water spout. This steep, biphasic dose response curve for the anticonflict actions of muscimol may explain contradictory findings in the literature concerning GABAergic involvement in the anxiolytic actions of benzodiazepines. The low dose of muscimol needed to produce a significant anticonflict effect in the lateral septum suggests that this nucleus may be a critical site in anxiety-related behaviors.

AB - Muscimol microinjected into the lateral septum of the rat produced a dose dependent increase in punished responding over the dose range of 100 pg-5 ng. The higher doses used (10 ng and 1 μg) produced sedation and ataxia, markedly reducing the number of approaches to the water spout. This steep, biphasic dose response curve for the anticonflict actions of muscimol may explain contradictory findings in the literature concerning GABAergic involvement in the anxiolytic actions of benzodiazepines. The low dose of muscimol needed to produce a significant anticonflict effect in the lateral septum suggests that this nucleus may be a critical site in anxiety-related behaviors.

UR - http://www.scopus.com/inward/record.url?scp=0022654749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022654749&partnerID=8YFLogxK

U2 - 10.1016/0028-3908(86)90042-0

DO - 10.1016/0028-3908(86)90042-0

M3 - Article

C2 - 3703171

AN - SCOPUS:0022654749

VL - 25

SP - 203

EP - 205

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 2

ER -