Low-dose heparin thromboembolism prophylaxis

John T Owings, F. William Blaisdell

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objective: To determine a rational approach to heparin dosing for thromboembolism prophylaxis. Design: Literature review. Results: Three commonly used heparin dosing regimens were identified: (1) standard low-dose heparin (5000 U administered subcutaneously 2-3 times per day); (2) adjusted- dose heparin (adequate to elevate the activated partial thromboplastin time to 5 seconds above the upper limit of normal); and (3) low-molecular-weight heparin (30 mg subcutaneously twice daily without monitoring). Conclusions: Adjusted-dose heparin thromboembolism prophylaxis is both the safest and most reliable method currently available.

Original languageEnglish (US)
Pages (from-to)1069-1073
Number of pages5
JournalArchives of Surgery
Issue number10
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Surgery


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