Low density lipoprotein receptors mediate Intracellular calcium signals in microalbuminuric hypertensives

Ronald L Fong, Jay V. Vadgama, Miriam R. Laguer, Harry J. Ward

Research output: Contribution to journalArticle

Abstract

Hyperlipidemia is an established risk factor for progressive renal damage and proteinuria. Platelets and vascular smooth muscle cells (VSMC) are known to possess low density lipoprotein (LDL) cholesterol receptors. We used platelet LDL receptors to investigate the hypothesis that elevated lipids could activate intracellular calcium [Ca2+](i) signals, leading to altered vascular tone and permeability. We divided essential hypertensives into microalbuminuric positive (MA+) and negative (MA-) groups and measured baseline and LDL stimulated levels of [Ca2+](i). The MA+ group demonstrated a significantly higher mean baseline [Ca2+](i) level (119.0 ± 24.5 v 86.2 ± 25.4 μmol/mL, P = .001). The MA+ group also displayed greater elevations in [Ca2+](i) levels after stimulation with LDL in concentrations of 10 and 25 μg/mL (100.9 ± 54.8 v 40.9 ± 20.2, P = .04 and 111.6 ± 51.0 v 52.9 ± 39.9 μmol/mL, P = .03, respectively). Our data indicate that hypertensive patients with early glomerular capillary injury display exaggerated influx of [Ca2+](i) after LDL receptor stimulation. Heightened LDL receptor sensitivity may facilitate LDL mediated [Ca2+](i) signals, leading to increased VSMC tone and proliferation and progressive renal disease.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalAmerican Journal of Hypertension
Volume11
Issue number1
DOIs
StatePublished - Jan 1998

Keywords

  • Hyperlipidemia
  • Intracellular calcium
  • LDL cholesterol
  • Microalbuminuria
  • Platelet

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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