Low-density lipoprotein oxidation, antioxidants, and atherosclerosis: A clinical biochemistry perspective

Ishwarlal Jialal, Sridevi Devaraj

Research output: Contribution to journalArticlepeer-review

197 Scopus citations

Abstract

Cardiovascular disease is the leading cause of mortality in westernized populations. An increased concentration of plasma low-density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerosis. Several lines of evidence support a role for oxidatively modified LDL in atherosclerosis and for its in vivo existence. Antioxidants have been shown to decrease atherosclerotic lesion formation in animal models and decrease LDL oxidation; the evaluation of LDL oxidation in vivo is therefore very important. However, there is a paucity of methods for direct measurement of LDL oxidation. Of the direct methods currently available, the preferred ones seem to be the measurement of F2-isoprostanes, autoantibodies to epitopes on oxidized LDL, and the assessment of antioxidant status. Of the indirect measures, the most uniformly accepted procedure is examining the oxidative susceptibility of isolated LDL by monitoring conjugated diene formation.

Original languageEnglish (US)
Pages (from-to)498-506
Number of pages9
JournalClinical Chemistry
Volume42
Issue number4
StatePublished - 1996
Externally publishedYes

Keywords

  • α-tocopherol
  • β- carotene
  • apolipoprotein B-100
  • ascorbate
  • cardiovascular disease
  • cholesterol
  • conjugated dienes
  • fatty acids
  • isoprostanes
  • prostaglandins
  • thiobarbituric acid-reactive substances

ASJC Scopus subject areas

  • Clinical Biochemistry

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