Loss of pigmented dopamine-β-hydroxylase positive cells from locus coeruleus in senile dementia of alzheimer's type

L. L. Iversen, M. N. Rossor, G. P. Reynolds, R. Hills, M. Roth, C. Q. Mountjoy, S. L. Foote, John Morrison, F. E. Bloom

Research output: Contribution to journalArticle

208 Scopus citations

Abstract

Serial sections of human brainstem were used to determine the total number of pigmented cells in locus coeruleus and, by immunohistochemical staining using an antiserum directed against human dopamine-β-hydroxylase (DBH), the number of DBH-positive cells. In 12 brains from elderly control and dementia subjects there were no significant differences in the total cell populations determined in the same brain by the two techniques. In 6 patients with senile dementia of Alzheimer's type there was a variable loss (average about 60% reduction) in locus coeruleus cells when compared to control similar age. The loss of noradrenergic neurones from locus coeruleus was accompanied by an average reduction of similar magnitude in noradrenaline concentration in temporal cortex, with no change or an increase in dopamine content. There was also a significant reduction in the cholinergic marker choline acetyltransferase in cortex samples from the dementia cases.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalNeuroscience Letters
Volume39
Issue number1
DOIs
StatePublished - Aug 19 1983
Externally publishedYes

Keywords

  • Alzheimer's type senile dementia
  • choline acetyltransferase
  • dopamine-β-hydroxylase
  • locus coeruleus
  • noradrenaline

ASJC Scopus subject areas

  • Neuroscience(all)

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    Iversen, L. L., Rossor, M. N., Reynolds, G. P., Hills, R., Roth, M., Mountjoy, C. Q., Foote, S. L., Morrison, J., & Bloom, F. E. (1983). Loss of pigmented dopamine-β-hydroxylase positive cells from locus coeruleus in senile dementia of alzheimer's type. Neuroscience Letters, 39(1), 95-100. https://doi.org/10.1016/0304-3940(83)90171-4