Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Gustavo Barisone; Noriko Satake; Carly Lewis; Connie Duong; Cathy Chen; Kit Lam; Jan Nolta; Elva D Diaz

doi:10.1016/j.bcmd.2014.12.002

Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Gustavo Barisone, Noriko Satake, Carly Lewis, Connie Duong, Cathy Chen, Kit Lam, Jan Nolta, Elva D Diaz

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

Original language	English (US)
Pages (from-to)	329-335
Number of pages	7
Journal	Blood Cells, Molecules, and Diseases
Volume	54
Issue number	4
DOIs	https://doi.org/10.1016/j.bcmd.2014.12.002
State	Published - Apr 1 2015

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Keywords

Apoptosis
MXD3
Precursor B acute lymphoblastic leukemia
Proliferation

ASJC Scopus subject areas

Molecular Medicine
Hematology
Molecular Biology
Cell Biology

Cite this

Barisone, G., Satake, N., Lewis, C., Duong, C., Chen, C., Lam, K., Nolta, J., & Diaz, E. D. (2015). Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells. Blood Cells, Molecules, and Diseases, 54(4), 329-335. https://doi.org/10.1016/j.bcmd.2014.12.002

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Access to Document

10.1016/j.bcmd.2014.12.002