Abstract
MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 329-335 |
| Number of pages | 7 |
| Journal | Blood Cells, Molecules, and Diseases |
| Volume | 54 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2015 |
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Keywords
- Apoptosis
- MXD3
- Precursor B acute lymphoblastic leukemia
- Proliferation
ASJC Scopus subject areas
- Molecular Medicine
- Hematology
- Molecular Biology
- Cell Biology
Cite this
Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells. / Barisone, Gustavo; Satake, Noriko; Lewis, Carly; Duong, Connie; Chen, Cathy; Lam, Kit; Nolta, Jan; Diaz, Elva D.
In: Blood Cells, Molecules, and Diseases, Vol. 54, No. 4, 01.04.2015, p. 329-335.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells
AU - Barisone, Gustavo
AU - Satake, Noriko
AU - Lewis, Carly
AU - Duong, Connie
AU - Chen, Cathy
AU - Lam, Kit
AU - Nolta, Jan
AU - Diaz, Elva D
PY - 2015/4/1
Y1 - 2015/4/1
N2 - MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
AB - MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
KW - Apoptosis
KW - MXD3
KW - Precursor B acute lymphoblastic leukemia
KW - Proliferation
UR - http://www.scopus.com/inward/record.url?scp=84961326624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961326624&partnerID=8YFLogxK
U2 - 10.1016/j.bcmd.2014.12.002
DO - 10.1016/j.bcmd.2014.12.002
M3 - Article
C2 - 25554682
AN - SCOPUS:84961326624
VL - 54
SP - 329
EP - 335
JO - Blood Cells, Molecules, and Diseases
JF - Blood Cells, Molecules, and Diseases
SN - 1079-9796
IS - 4
ER -