Abstract
MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
Original language | English (US) |
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Pages (from-to) | 329-335 |
Number of pages | 7 |
Journal | Blood Cells, Molecules, and Diseases |
Volume | 54 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2015 |
Keywords
- Apoptosis
- MXD3
- Precursor B acute lymphoblastic leukemia
- Proliferation
ASJC Scopus subject areas
- Molecular Medicine
- Hematology
- Molecular Biology
- Cell Biology