Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Gustavo Barisone, Noriko Satake, Carly Lewis, Connie Duong, Cathy Chen, Kit Lam, Jan Nolta, Elva D Diaz

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

Original languageEnglish (US)
Pages (from-to)329-335
Number of pages7
JournalBlood Cells, Molecules, and Diseases
Volume54
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Apoptosis
  • MXD3
  • Precursor B acute lymphoblastic leukemia
  • Proliferation

ASJC Scopus subject areas

  • Molecular Medicine
  • Hematology
  • Molecular Biology
  • Cell Biology

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