Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Gustavo Barisone, Noriko Satake, Carly Lewis, Connie Duong, Cathy Chen, Kit Lam, Jan Nolta, Elva D Diaz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

Original languageEnglish (US)
Pages (from-to)329-335
Number of pages7
JournalBlood Cells, Molecules, and Diseases
Volume54
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Apoptosis
Medulloblastoma
Hematopoietic Stem Cells
Blood Cells
Transcription Factors
Cell Count
Bone Marrow
Cell Line
Survival
Population

Keywords

  • Apoptosis
  • MXD3
  • Precursor B acute lymphoblastic leukemia
  • Proliferation

ASJC Scopus subject areas

  • Molecular Medicine
  • Hematology
  • Molecular Biology
  • Cell Biology

Cite this

Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells. / Barisone, Gustavo; Satake, Noriko; Lewis, Carly; Duong, Connie; Chen, Cathy; Lam, Kit; Nolta, Jan; Diaz, Elva D.

In: Blood Cells, Molecules, and Diseases, Vol. 54, No. 4, 01.04.2015, p. 329-335.

Research output: Contribution to journalArticle

@article{a13b87d20df946fe887807250ae07b78,
title = "Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells",
abstract = "MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.",
keywords = "Apoptosis, MXD3, Precursor B acute lymphoblastic leukemia, Proliferation",
author = "Gustavo Barisone and Noriko Satake and Carly Lewis and Connie Duong and Cathy Chen and Kit Lam and Jan Nolta and Diaz, {Elva D}",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.bcmd.2014.12.002",
language = "English (US)",
volume = "54",
pages = "329--335",
journal = "Blood Cells, Molecules, and Diseases",
issn = "1079-9796",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

AU - Barisone, Gustavo

AU - Satake, Noriko

AU - Lewis, Carly

AU - Duong, Connie

AU - Chen, Cathy

AU - Lam, Kit

AU - Nolta, Jan

AU - Diaz, Elva D

PY - 2015/4/1

Y1 - 2015/4/1

N2 - MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

AB - MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

KW - Apoptosis

KW - MXD3

KW - Precursor B acute lymphoblastic leukemia

KW - Proliferation

UR - http://www.scopus.com/inward/record.url?scp=84961326624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961326624&partnerID=8YFLogxK

U2 - 10.1016/j.bcmd.2014.12.002

DO - 10.1016/j.bcmd.2014.12.002

M3 - Article

C2 - 25554682

AN - SCOPUS:84961326624

VL - 54

SP - 329

EP - 335

JO - Blood Cells, Molecules, and Diseases

JF - Blood Cells, Molecules, and Diseases

SN - 1079-9796

IS - 4

ER -