Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Gustavo Barisone; Noriko Satake; Carly Lewis; Connie Duong; Cathy Chen; Kit Lam; Jan Nolta; Elva D Diaz

doi:10.1016/j.bcmd.2014.12.002

Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Gustavo Barisone, Noriko Satake, Carly Lewis, Connie Duong, Cathy Chen, Kit Lam, Jan Nolta, Elva D Diaz

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

Original language	English (US)
Pages (from-to)	329-335
Number of pages	7
Journal	Blood Cells, Molecules, and Diseases
Volume	54
Issue number	4
DOIs	https://doi.org/10.1016/j.bcmd.2014.12.002
State	Published - Apr 1 2015

Keywords

Apoptosis
MXD3
Precursor B acute lymphoblastic leukemia
Proliferation

ASJC Scopus subject areas

Molecular Medicine
Hematology
Molecular Biology
Cell Biology

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10.1016/j.bcmd.2014.12.002

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title = "Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells",

abstract = "MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.",

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AU - Barisone, Gustavo

AU - Satake, Noriko

AU - Lewis, Carly

AU - Duong, Connie

AU - Chen, Cathy

AU - Lam, Kit

AU - Nolta, Jan

AU - Diaz, Elva D

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AB - MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

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KW - Precursor B acute lymphoblastic leukemia

KW - Proliferation

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Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Abstract

Keywords

ASJC Scopus subject areas

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