Loss of heterozygosity on chromosome 11 in sporadic gastrinomas

Mark P. Sawicki, Yu-Jui Yvonne Wan, Carey L. Johnson, James Berenson, Richard Gatti, Edward Passaro

Research output: Contribution to journalArticle

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Abstract

Gastrinomas are pancreatic endocrine neoplasms that arise either sporadically or are inherited as part of the multiple endocrine neoplasia type I syndrome (MEN I). Loss of heterozygosity (LOH) in the region flanking the MEN I gene at chromosome 11q13 has been documented in a few sporadic and familial pancreatic endocrine tumors, but not previously in sporadic gastrinomas. It has therefore been suggested that gastrinomas develop by a mechanism different from other tumors associated with the MENI syndsrome. We report LOH on chromosome 11 in 5 of 11 sporadic gastrinomas. Four of these tumors have LOH for markers flanking the MEN I region. Molecular evaluation of segments of chromosomes 3, 13, and 17 known to contain cloned or putative tumor suppressor genes fail to show LOH except at one locus in one tumor. These data suggest that a tumor suppressor DNA segment exists at 11q13 that may be involved in the development of sporadic gastrinomas.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalHuman Genetics
Volume89
Issue number4
DOIs
StatePublished - Jun 1992

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Gastrinoma
Chromosomes, Human, Pair 11
Loss of Heterozygosity
Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia Type 1
Neoplasms
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 3
Tumor Suppressor Genes
Pancreatic Neoplasms
Chromosomes
DNA
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Sawicki, M. P., Wan, Y-J. Y., Johnson, C. L., Berenson, J., Gatti, R., & Passaro, E. (1992). Loss of heterozygosity on chromosome 11 in sporadic gastrinomas. Human Genetics, 89(4), 445-449. https://doi.org/10.1007/BF00194320

Loss of heterozygosity on chromosome 11 in sporadic gastrinomas. / Sawicki, Mark P.; Wan, Yu-Jui Yvonne; Johnson, Carey L.; Berenson, James; Gatti, Richard; Passaro, Edward.

In: Human Genetics, Vol. 89, No. 4, 06.1992, p. 445-449.

Research output: Contribution to journalArticle

Sawicki, MP, Wan, Y-JY, Johnson, CL, Berenson, J, Gatti, R & Passaro, E 1992, 'Loss of heterozygosity on chromosome 11 in sporadic gastrinomas', Human Genetics, vol. 89, no. 4, pp. 445-449. https://doi.org/10.1007/BF00194320
Sawicki MP, Wan Y-JY, Johnson CL, Berenson J, Gatti R, Passaro E. Loss of heterozygosity on chromosome 11 in sporadic gastrinomas. Human Genetics. 1992 Jun;89(4):445-449. https://doi.org/10.1007/BF00194320
Sawicki, Mark P. ; Wan, Yu-Jui Yvonne ; Johnson, Carey L. ; Berenson, James ; Gatti, Richard ; Passaro, Edward. / Loss of heterozygosity on chromosome 11 in sporadic gastrinomas. In: Human Genetics. 1992 ; Vol. 89, No. 4. pp. 445-449.
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