Longitudinal survey of knockdown resistance to pyrethroid (KDR) in Mali, West Africa, and evidence of its emergence in the Bamako form of Anopheles gambiae s.s.

Frederic Tripet, Jennifer Wright, Anthon Cornel, Abdrahamane Fofana, Rory McAbee, Claudio Meneses, Lisa Reimer, Michel Slotman, Tara Thiemann, Guimogo Dolo, Sekou Traoré, Gregory C Lanzaro

Research output: Contribution to journalArticle

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Abstract

Studies aimed at monitoring the spread of knockdown resistance to pyrethroids (kdr) in time and space are particularly useful for detecting barriers to gene flow among the chromosomal and molecular forms of Anopheles gambiae. We used a recently developed polymerase chain reaction assay to estimate changes in kdr frequency that occurred in several mixed-form populations from Mali, West Africa, in the past decade. We found that the kdr allele significantly increased in frequency in most populations but was still absent from the M molecular form. Importantly, within the S molecular form, kdr was detected for the first time in the Bamako chromosomal form. These results provide important insights on the patterns of spread and emergence of pyrethroid knockdown resistance in West Africa.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number1
StatePublished - Jan 2007

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Mali
Anopheles gambiae
Pyrethrins
Western Africa
Longitudinal Studies
Gene Flow
Population
Alleles
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Longitudinal survey of knockdown resistance to pyrethroid (KDR) in Mali, West Africa, and evidence of its emergence in the Bamako form of Anopheles gambiae s.s. / Tripet, Frederic; Wright, Jennifer; Cornel, Anthon; Fofana, Abdrahamane; McAbee, Rory; Meneses, Claudio; Reimer, Lisa; Slotman, Michel; Thiemann, Tara; Dolo, Guimogo; Traoré, Sekou; Lanzaro, Gregory C.

In: American Journal of Tropical Medicine and Hygiene, Vol. 76, No. 1, 01.2007, p. 81-87.

Research output: Contribution to journalArticle

Tripet, F, Wright, J, Cornel, A, Fofana, A, McAbee, R, Meneses, C, Reimer, L, Slotman, M, Thiemann, T, Dolo, G, Traoré, S & Lanzaro, GC 2007, 'Longitudinal survey of knockdown resistance to pyrethroid (KDR) in Mali, West Africa, and evidence of its emergence in the Bamako form of Anopheles gambiae s.s.', American Journal of Tropical Medicine and Hygiene, vol. 76, no. 1, pp. 81-87.
Tripet, Frederic ; Wright, Jennifer ; Cornel, Anthon ; Fofana, Abdrahamane ; McAbee, Rory ; Meneses, Claudio ; Reimer, Lisa ; Slotman, Michel ; Thiemann, Tara ; Dolo, Guimogo ; Traoré, Sekou ; Lanzaro, Gregory C. / Longitudinal survey of knockdown resistance to pyrethroid (KDR) in Mali, West Africa, and evidence of its emergence in the Bamako form of Anopheles gambiae s.s. In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 76, No. 1. pp. 81-87.
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