Longitudinal patterns of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesviruses in age-structured captive breeding populations of rhesus macaques (Macaca mulatta)

Jessica A. White, Xiaowei Yang, Patricia A. Todd, Nicholas W. Lerche

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Rhesus rhadinovirus (RRV) and retroperitoneal fibromatosis herpesvirus (RFHV), 2 closely related γ2 herpesviruses, are endemic in breeding populations of rhesus macaques at our institution. We previously reported significantly different prevalence levels, suggesting the transmission dynamics of RRV and RFHV differ with regard to viral shedding and infectivity. We designed a longitudinal study to further examine the previously observed differences between RRV and RFHV prevalence and the potential influence of age, season, and housing location on the same 90 rhesus macaques previously studied. Virus- and host-genome-specific real-time PCR assays were used to determine viral loads for both RRV and RFHV in blood and saliva samples collected at 6 time points over an 18-mo period. Proportions of positive animals and viral load in blood and saliva were compared between and within viruses by age group, location, and season by using 2-part longitudinal modeling with Bayesian inferences. Our results demonstrate that age and season are significant determinants, with age as the most significant factor analyzed, of viremia and oral shedding for both RRV and RFHV, and these pathogens exhibit distinctly different patterns of viremia and oral shedding over time within a single population.

Original languageEnglish (US)
Pages (from-to)60-70
Number of pages11
JournalComparative Medicine
Volume61
Issue number1
StatePublished - Feb 2011

Keywords

  • Kaposi sarcoma herpesvirus
  • KSHV
  • Oncostatin M
  • OSM
  • Retroperitoneal fibromatosis herpesvirus
  • RFHV
  • Rhesus rhadinovirus
  • RRV

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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