Longitudinal gray matter contraction in three variants of primary progressive aphasia

A tenser-based morphometry study

Simona Maria Brambati, Serena Amici, Caroline A. Racine, John Neuhaus, Zachary Miller, Jenny Ogar, Nina Dronkers, Bruce L. Miller, Howard Rosen, Maria Luisa Gorno-Tempini

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.

Original languageEnglish (US)
Pages (from-to)345-355
Number of pages11
JournalNeuroImage: Clinical
Volume8
DOIs
StatePublished - Jun 8 2015

Fingerprint

Primary Progressive Aphasia
Atrophy
Semantics
Primary Progressive Nonfluent Aphasia
Parietal Lobe
Aptitude
Executive Function
Temporal Lobe
Gray Matter
Cognition
Anatomy
Language

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Neurology

Cite this

Brambati, S. M., Amici, S., Racine, C. A., Neuhaus, J., Miller, Z., Ogar, J., ... Gorno-Tempini, M. L. (2015). Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study. NeuroImage: Clinical, 8, 345-355. https://doi.org/10.1016/j.nicl.2015.01.011

Longitudinal gray matter contraction in three variants of primary progressive aphasia : A tenser-based morphometry study. / Brambati, Simona Maria; Amici, Serena; Racine, Caroline A.; Neuhaus, John; Miller, Zachary; Ogar, Jenny; Dronkers, Nina; Miller, Bruce L.; Rosen, Howard; Gorno-Tempini, Maria Luisa.

In: NeuroImage: Clinical, Vol. 8, 08.06.2015, p. 345-355.

Research output: Contribution to journalArticle

Brambati, SM, Amici, S, Racine, CA, Neuhaus, J, Miller, Z, Ogar, J, Dronkers, N, Miller, BL, Rosen, H & Gorno-Tempini, ML 2015, 'Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study', NeuroImage: Clinical, vol. 8, pp. 345-355. https://doi.org/10.1016/j.nicl.2015.01.011
Brambati, Simona Maria ; Amici, Serena ; Racine, Caroline A. ; Neuhaus, John ; Miller, Zachary ; Ogar, Jenny ; Dronkers, Nina ; Miller, Bruce L. ; Rosen, Howard ; Gorno-Tempini, Maria Luisa. / Longitudinal gray matter contraction in three variants of primary progressive aphasia : A tenser-based morphometry study. In: NeuroImage: Clinical. 2015 ; Vol. 8. pp. 345-355.
@article{55be73d07abe41ce9bf6a35fe92111a2,
title = "Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study",
abstract = "The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.",
author = "Brambati, {Simona Maria} and Serena Amici and Racine, {Caroline A.} and John Neuhaus and Zachary Miller and Jenny Ogar and Nina Dronkers and Miller, {Bruce L.} and Howard Rosen and Gorno-Tempini, {Maria Luisa}",
year = "2015",
month = "6",
day = "8",
doi = "10.1016/j.nicl.2015.01.011",
language = "English (US)",
volume = "8",
pages = "345--355",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Longitudinal gray matter contraction in three variants of primary progressive aphasia

T2 - A tenser-based morphometry study

AU - Brambati, Simona Maria

AU - Amici, Serena

AU - Racine, Caroline A.

AU - Neuhaus, John

AU - Miller, Zachary

AU - Ogar, Jenny

AU - Dronkers, Nina

AU - Miller, Bruce L.

AU - Rosen, Howard

AU - Gorno-Tempini, Maria Luisa

PY - 2015/6/8

Y1 - 2015/6/8

N2 - The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.

AB - The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.

UR - http://www.scopus.com/inward/record.url?scp=84930626896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930626896&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2015.01.011

DO - 10.1016/j.nicl.2015.01.011

M3 - Article

VL - 8

SP - 345

EP - 355

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -