Longitudinal community walking activity in Duchenne muscular dystrophy

Eileen G. Fowler, Loretta A. Staudt, Kent R. Heberer, Susan E. Sienko, Cathleen E. Buckon, Anita M. Bagley, Michael D. Sussman, Craig M McDonald

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Introduction: Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. Methods: Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4-16 years) with DMD with serial enrollment up to 5 years by using a repeated-measures mixed model. Additionally, data were compared with 10-meter walk/run (10mWR) speed to determine validity and sensitivity. Results: There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age (P<0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline (P<0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed (P<0.05). Discussion: Community ambulation data provide valid and sensitive real-world measures that may inform clinical trials.

Original languageEnglish (US)
JournalMuscle and Nerve
DOIs
StateAccepted/In press - 2017

Keywords

  • Accelerometry
  • Community walking
  • Duchenne muscular dystrophy
  • Gait
  • Natural history
  • Physical activity

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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  • Cite this

    Fowler, E. G., Staudt, L. A., Heberer, K. R., Sienko, S. E., Buckon, C. E., Bagley, A. M., Sussman, M. D., & McDonald, C. M. (Accepted/In press). Longitudinal community walking activity in Duchenne muscular dystrophy. Muscle and Nerve. https://doi.org/10.1002/mus.25743