Longitudinal community walking activity in Duchenne muscular dystrophy

Eileen G. Fowler; Loretta A. Staudt; Kent R. Heberer; Susan E. Sienko; Cathleen E. Buckon; Anita M. Bagley; Michael D. Sussman; Craig M McDonald

doi:10.1002/mus.25743

Longitudinal community walking activity in Duchenne muscular dystrophy

Eileen G. Fowler, Loretta A. Staudt, Kent R. Heberer, Susan E. Sienko, Cathleen E. Buckon, Anita M. Bagley, Michael D. Sussman, Craig M McDonald

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Introduction: Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. Methods: Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4-16 years) with DMD with serial enrollment up to 5 years by using a repeated-measures mixed model. Additionally, data were compared with 10-meter walk/run (10mWR) speed to determine validity and sensitivity. Results: There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age (P<0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline (P<0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed (P<0.05). Discussion: Community ambulation data provide valid and sensitive real-world measures that may inform clinical trials.

Original language	English (US)
Journal	Muscle and Nerve
DOIs	https://doi.org/10.1002/mus.25743
State	Accepted/In press - 2017

Keywords

Accelerometry
Community walking
Duchenne muscular dystrophy
Gait
Natural history
Physical activity

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.25743

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title = "Longitudinal community walking activity in Duchenne muscular dystrophy",

abstract = "Introduction: Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. Methods: Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4-16 years) with DMD with serial enrollment up to 5 years by using a repeated-measures mixed model. Additionally, data were compared with 10-meter walk/run (10mWR) speed to determine validity and sensitivity. Results: There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age (P<0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline (P<0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed (P<0.05). Discussion: Community ambulation data provide valid and sensitive real-world measures that may inform clinical trials.",

keywords = "Accelerometry, Community walking, Duchenne muscular dystrophy, Gait, Natural history, Physical activity",

author = "Fowler, {Eileen G.} and Staudt, {Loretta A.} and Heberer, {Kent R.} and Sienko, {Susan E.} and Buckon, {Cathleen E.} and Bagley, {Anita M.} and Sussman, {Michael D.} and McDonald, {Craig M}",

year = "2017",

doi = "10.1002/mus.25743",

language = "English (US)",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "John Wiley and Sons Inc.",

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T1 - Longitudinal community walking activity in Duchenne muscular dystrophy

AU - Fowler, Eileen G.

AU - Staudt, Loretta A.

AU - Heberer, Kent R.

AU - Sienko, Susan E.

AU - Buckon, Cathleen E.

AU - Bagley, Anita M.

AU - Sussman, Michael D.

AU - McDonald, Craig M

PY - 2017

Y1 - 2017

N2 - Introduction: Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. Methods: Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4-16 years) with DMD with serial enrollment up to 5 years by using a repeated-measures mixed model. Additionally, data were compared with 10-meter walk/run (10mWR) speed to determine validity and sensitivity. Results: There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age (P<0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline (P<0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed (P<0.05). Discussion: Community ambulation data provide valid and sensitive real-world measures that may inform clinical trials.

AB - Introduction: Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. Methods: Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4-16 years) with DMD with serial enrollment up to 5 years by using a repeated-measures mixed model. Additionally, data were compared with 10-meter walk/run (10mWR) speed to determine validity and sensitivity. Results: There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age (P<0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline (P<0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed (P<0.05). Discussion: Community ambulation data provide valid and sensitive real-world measures that may inform clinical trials.

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KW - Duchenne muscular dystrophy

KW - Gait

KW - Natural history

KW - Physical activity

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