Longitudinal changes in volumetric breast density in healthy women across the menopausal transition

Natalie J. Engmann, Christopher Scott, Matthew R. Jensen, Stacey J. Winham, Lin Ma, Kathleen R. Brandt, Amir Mahmoudzadeh, Dana H. Whaley, Carrie B. Hruska, Fang Fang Wu, Aaron D. Norman, Robert A. Hiatt, John Heine, John Shepherd, V. Shane Pankratz, Diana L Miglioretti, Karla Kerlikowske, Celine M. Vachon

Research output: Contribution to journalArticle

Abstract

Background: Mammographic breast density declines during menopause. We assessed changes in volumetric breast density across the menopausal transition and factors that influence these changes. Methods: Womenwithout a history of breast cancer,who had full field digital mammograms during both pre- and postmenopausal periods, at least 2 years apart, were sampled from four facilities within the San Francisco Mammography Registry from 2007 to 2013. Dense breast volume (DV) was assessed using Volpara on mammograms across the time period. Annualized change in DV from pre- to postmenopause was estimated using linear mixed models adjusted for covariates and per-woman random effects. Multiplicative interactions were evaluated between premenopausal risk factors and time to determine whether these covariates modified the annualized changes. Results: Among the 2,586 eligible women, 1,802 had one premenopausal and one postmenopausal mammogram, 628 had an additional perimenopausal mammogram, and 156 had two perimenopausal mammograms. Women experienced an annualized decrease in DV [-2.2 cm3 (95% confidence interval, -2.7 to -1.7)] over the menopausal transition. Declines were greater among women with a premenopausal DV above the median (54 cm3) versus below (DV, -3.5 cm3 vs. -1.0 cm3; P < 0.0001). Other breast cancer risk factors, including race, body mass index, family history, alcohol, and postmenopausal hormone therapy, had no effect on change in DV over the menopausal transition. Conclusions: High premenopausal DV was a strong predictor of greater reductions in DV across the menopausal transition. Impact: We found that few factors other than premenopausal density influence changes in DV across the menopausal transition, limiting targeted prevention efforts.

Original languageEnglish (US)
Pages (from-to)1324-1331
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume28
Issue number8
DOIs
StatePublished - Jan 1 2019

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Breast
Postmenopause
Premenopause
Breast Neoplasms
Breast Density
San Francisco
Mammography
Menopause
Registries
Linear Models
Body Mass Index
Alcohols
Hormones
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Engmann, N. J., Scott, C., Jensen, M. R., Winham, S. J., Ma, L., Brandt, K. R., ... Vachon, C. M. (2019). Longitudinal changes in volumetric breast density in healthy women across the menopausal transition. Cancer Epidemiology Biomarkers and Prevention, 28(8), 1324-1331. https://doi.org/10.1158/1055-9965.EPI-18-1375

Longitudinal changes in volumetric breast density in healthy women across the menopausal transition. / Engmann, Natalie J.; Scott, Christopher; Jensen, Matthew R.; Winham, Stacey J.; Ma, Lin; Brandt, Kathleen R.; Mahmoudzadeh, Amir; Whaley, Dana H.; Hruska, Carrie B.; Wu, Fang Fang; Norman, Aaron D.; Hiatt, Robert A.; Heine, John; Shepherd, John; Shane Pankratz, V.; Miglioretti, Diana L; Kerlikowske, Karla; Vachon, Celine M.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 28, No. 8, 01.01.2019, p. 1324-1331.

Research output: Contribution to journalArticle

Engmann, NJ, Scott, C, Jensen, MR, Winham, SJ, Ma, L, Brandt, KR, Mahmoudzadeh, A, Whaley, DH, Hruska, CB, Wu, FF, Norman, AD, Hiatt, RA, Heine, J, Shepherd, J, Shane Pankratz, V, Miglioretti, DL, Kerlikowske, K & Vachon, CM 2019, 'Longitudinal changes in volumetric breast density in healthy women across the menopausal transition', Cancer Epidemiology Biomarkers and Prevention, vol. 28, no. 8, pp. 1324-1331. https://doi.org/10.1158/1055-9965.EPI-18-1375
Engmann, Natalie J. ; Scott, Christopher ; Jensen, Matthew R. ; Winham, Stacey J. ; Ma, Lin ; Brandt, Kathleen R. ; Mahmoudzadeh, Amir ; Whaley, Dana H. ; Hruska, Carrie B. ; Wu, Fang Fang ; Norman, Aaron D. ; Hiatt, Robert A. ; Heine, John ; Shepherd, John ; Shane Pankratz, V. ; Miglioretti, Diana L ; Kerlikowske, Karla ; Vachon, Celine M. / Longitudinal changes in volumetric breast density in healthy women across the menopausal transition. In: Cancer Epidemiology Biomarkers and Prevention. 2019 ; Vol. 28, No. 8. pp. 1324-1331.
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abstract = "Background: Mammographic breast density declines during menopause. We assessed changes in volumetric breast density across the menopausal transition and factors that influence these changes. Methods: Womenwithout a history of breast cancer,who had full field digital mammograms during both pre- and postmenopausal periods, at least 2 years apart, were sampled from four facilities within the San Francisco Mammography Registry from 2007 to 2013. Dense breast volume (DV) was assessed using Volpara on mammograms across the time period. Annualized change in DV from pre- to postmenopause was estimated using linear mixed models adjusted for covariates and per-woman random effects. Multiplicative interactions were evaluated between premenopausal risk factors and time to determine whether these covariates modified the annualized changes. Results: Among the 2,586 eligible women, 1,802 had one premenopausal and one postmenopausal mammogram, 628 had an additional perimenopausal mammogram, and 156 had two perimenopausal mammograms. Women experienced an annualized decrease in DV [-2.2 cm3 (95{\%} confidence interval, -2.7 to -1.7)] over the menopausal transition. Declines were greater among women with a premenopausal DV above the median (54 cm3) versus below (DV, -3.5 cm3 vs. -1.0 cm3; P < 0.0001). Other breast cancer risk factors, including race, body mass index, family history, alcohol, and postmenopausal hormone therapy, had no effect on change in DV over the menopausal transition. Conclusions: High premenopausal DV was a strong predictor of greater reductions in DV across the menopausal transition. Impact: We found that few factors other than premenopausal density influence changes in DV across the menopausal transition, limiting targeted prevention efforts.",
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T1 - Longitudinal changes in volumetric breast density in healthy women across the menopausal transition

AU - Engmann, Natalie J.

AU - Scott, Christopher

AU - Jensen, Matthew R.

AU - Winham, Stacey J.

AU - Ma, Lin

AU - Brandt, Kathleen R.

AU - Mahmoudzadeh, Amir

AU - Whaley, Dana H.

AU - Hruska, Carrie B.

AU - Wu, Fang Fang

AU - Norman, Aaron D.

AU - Hiatt, Robert A.

AU - Heine, John

AU - Shepherd, John

AU - Shane Pankratz, V.

AU - Miglioretti, Diana L

AU - Kerlikowske, Karla

AU - Vachon, Celine M.

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Y1 - 2019/1/1

N2 - Background: Mammographic breast density declines during menopause. We assessed changes in volumetric breast density across the menopausal transition and factors that influence these changes. Methods: Womenwithout a history of breast cancer,who had full field digital mammograms during both pre- and postmenopausal periods, at least 2 years apart, were sampled from four facilities within the San Francisco Mammography Registry from 2007 to 2013. Dense breast volume (DV) was assessed using Volpara on mammograms across the time period. Annualized change in DV from pre- to postmenopause was estimated using linear mixed models adjusted for covariates and per-woman random effects. Multiplicative interactions were evaluated between premenopausal risk factors and time to determine whether these covariates modified the annualized changes. Results: Among the 2,586 eligible women, 1,802 had one premenopausal and one postmenopausal mammogram, 628 had an additional perimenopausal mammogram, and 156 had two perimenopausal mammograms. Women experienced an annualized decrease in DV [-2.2 cm3 (95% confidence interval, -2.7 to -1.7)] over the menopausal transition. Declines were greater among women with a premenopausal DV above the median (54 cm3) versus below (DV, -3.5 cm3 vs. -1.0 cm3; P < 0.0001). Other breast cancer risk factors, including race, body mass index, family history, alcohol, and postmenopausal hormone therapy, had no effect on change in DV over the menopausal transition. Conclusions: High premenopausal DV was a strong predictor of greater reductions in DV across the menopausal transition. Impact: We found that few factors other than premenopausal density influence changes in DV across the menopausal transition, limiting targeted prevention efforts.

AB - Background: Mammographic breast density declines during menopause. We assessed changes in volumetric breast density across the menopausal transition and factors that influence these changes. Methods: Womenwithout a history of breast cancer,who had full field digital mammograms during both pre- and postmenopausal periods, at least 2 years apart, were sampled from four facilities within the San Francisco Mammography Registry from 2007 to 2013. Dense breast volume (DV) was assessed using Volpara on mammograms across the time period. Annualized change in DV from pre- to postmenopause was estimated using linear mixed models adjusted for covariates and per-woman random effects. Multiplicative interactions were evaluated between premenopausal risk factors and time to determine whether these covariates modified the annualized changes. Results: Among the 2,586 eligible women, 1,802 had one premenopausal and one postmenopausal mammogram, 628 had an additional perimenopausal mammogram, and 156 had two perimenopausal mammograms. Women experienced an annualized decrease in DV [-2.2 cm3 (95% confidence interval, -2.7 to -1.7)] over the menopausal transition. Declines were greater among women with a premenopausal DV above the median (54 cm3) versus below (DV, -3.5 cm3 vs. -1.0 cm3; P < 0.0001). Other breast cancer risk factors, including race, body mass index, family history, alcohol, and postmenopausal hormone therapy, had no effect on change in DV over the menopausal transition. Conclusions: High premenopausal DV was a strong predictor of greater reductions in DV across the menopausal transition. Impact: We found that few factors other than premenopausal density influence changes in DV across the menopausal transition, limiting targeted prevention efforts.

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