Abstract
Purpose: We evaluated the long-term urological complications in survivors of infant advanced stage abdominal neuroblastoma. Materials and Methods: The records of patients who presented during an 8-year period with surgical problems related to the kidney and who had survived advanced stage (IV and IV-S) neuroblastoma were reviewed. Results: Of 7 patients identified 3 had complications of obstruction from retroperitoneal fibrosis and 4 had renal cell carcinoma. In the renal cell carcinoma group 3 patients had synchronous, multifocal, bilateral tumors and 1 had a tumor in a solitary kidney. Pathological examination of renal cell carcinoma revealed oncocytoidy with solid and papillary patterns. One patient underwent bilateral nephrectomy but in the remaining 3 renal preservation surgery was performed. All 7 patients have no progression of secondary complications 2 to 8 years after initial presentation. Conclusions: Survivors of advanced stage abdominal neuroblastoma may be predisposed to long-term urological complications well after initial diagnosis. Because of the risk of renal damage from obstruction secondary to retroperitoneal fibrosis, and the propensity to have renal cell carcinoma, close long-term followup using abdominal imaging is recommended.
Original language | English (US) |
---|---|
Pages (from-to) | 1455-1458 |
Number of pages | 4 |
Journal | Journal of Urology |
Volume | 166 |
Issue number | 4 |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Abnormalities
- Neoplasms
- Neuroblastoma
ASJC Scopus subject areas
- Urology