Long-term survivors of childhood bone and soft tissue sarcomas are at risk of hospitalization

Cristian D. Gonzalez, R Randall, Jennifer Wright, Holly Spraker-Perlman, Jian Ying, Carol Sweeney, Ken R. Smith, Anne C. Kirchhoff

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Childhood cancer survivors can have a high burden of chronic conditions related to cancer treatment, some of which are debilitating or potentially life-threatening. Much remains to be learned about late effects in bone and soft tissue sarcoma survivors. Procedures: The Utah Cancer Registry was used to identify survivors of bone (N = 71) and soft tissue sarcomas (N = 98) who were diagnosed at ages 0–20 years between 1973 and 2007 and were alive at least 5 years after diagnosis. We selected an age–sex-matched comparison cohort (N = 934). Hospitalizations from 1996 to 2012 were extracted from the Utah Department of Health statewide inpatient hospitalization discharge records. Cox, Poisson, and Gamma regressions were used to evaluate the risk of hospitalization, rate of admission, and length of stay for survivors versus the comparison cohort. Primary ICD-9 codes defined the most common reasons for hospitalizations. Results: The hazard ratio (HR) of any hospitalization was higher for survivors in reference to the comparison cohort (HR = 2.12, 95% confidence interval [CI] 1.51–2.97). Survivors experienced more hospital admissions (rate ratio [RR] = 4.58, 95% CI 3.92–5.35) and longer length of stay (RR = 1.28, 95% CI 1.12–1.46) compared with the comparison cohort. Survivors treated with any chemotherapy were at three-fold higher risk (HR = 3.37, 95% CI 1.94–5.83) of hospitalization compared with survivors who received surgery and/or radiation alone. Among hospitalized survivors, the most common reason was injury for bone tumor (26.8%) and neoplasm for soft tissue sarcoma (12.2%). Conclusion: Childhood survivors of bone tumor and soft tissue sarcoma face ongoing risk of hospitalization for years after diagnosis.

Original languageEnglish (US)
Article numbere26371
JournalPediatric Blood and Cancer
Volume64
Issue number6
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Sarcoma
Survivors
Hospitalization
Bone and Bones
Confidence Intervals
International Classification of Diseases
Neoplasms
Length of Stay
Second Primary Neoplasms
Registries
Inpatients
Odds Ratio
Radiation
Drug Therapy
Health
Wounds and Injuries

Keywords

  • AYA
  • bone and soft tissue sarcoma
  • child and adolescent cancer
  • survivorship
  • Utah Population Database

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Gonzalez, C. D., Randall, R., Wright, J., Spraker-Perlman, H., Ying, J., Sweeney, C., ... Kirchhoff, A. C. (2017). Long-term survivors of childhood bone and soft tissue sarcomas are at risk of hospitalization. Pediatric Blood and Cancer, 64(6), [e26371]. https://doi.org/10.1002/pbc.26371

Long-term survivors of childhood bone and soft tissue sarcomas are at risk of hospitalization. / Gonzalez, Cristian D.; Randall, R; Wright, Jennifer; Spraker-Perlman, Holly; Ying, Jian; Sweeney, Carol; Smith, Ken R.; Kirchhoff, Anne C.

In: Pediatric Blood and Cancer, Vol. 64, No. 6, e26371, 01.06.2017.

Research output: Contribution to journalArticle

Gonzalez, CD, Randall, R, Wright, J, Spraker-Perlman, H, Ying, J, Sweeney, C, Smith, KR & Kirchhoff, AC 2017, 'Long-term survivors of childhood bone and soft tissue sarcomas are at risk of hospitalization', Pediatric Blood and Cancer, vol. 64, no. 6, e26371. https://doi.org/10.1002/pbc.26371
Gonzalez, Cristian D. ; Randall, R ; Wright, Jennifer ; Spraker-Perlman, Holly ; Ying, Jian ; Sweeney, Carol ; Smith, Ken R. ; Kirchhoff, Anne C. / Long-term survivors of childhood bone and soft tissue sarcomas are at risk of hospitalization. In: Pediatric Blood and Cancer. 2017 ; Vol. 64, No. 6.
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abstract = "Background: Childhood cancer survivors can have a high burden of chronic conditions related to cancer treatment, some of which are debilitating or potentially life-threatening. Much remains to be learned about late effects in bone and soft tissue sarcoma survivors. Procedures: The Utah Cancer Registry was used to identify survivors of bone (N = 71) and soft tissue sarcomas (N = 98) who were diagnosed at ages 0–20 years between 1973 and 2007 and were alive at least 5 years after diagnosis. We selected an age–sex-matched comparison cohort (N = 934). Hospitalizations from 1996 to 2012 were extracted from the Utah Department of Health statewide inpatient hospitalization discharge records. Cox, Poisson, and Gamma regressions were used to evaluate the risk of hospitalization, rate of admission, and length of stay for survivors versus the comparison cohort. Primary ICD-9 codes defined the most common reasons for hospitalizations. Results: The hazard ratio (HR) of any hospitalization was higher for survivors in reference to the comparison cohort (HR = 2.12, 95{\%} confidence interval [CI] 1.51–2.97). Survivors experienced more hospital admissions (rate ratio [RR] = 4.58, 95{\%} CI 3.92–5.35) and longer length of stay (RR = 1.28, 95{\%} CI 1.12–1.46) compared with the comparison cohort. Survivors treated with any chemotherapy were at three-fold higher risk (HR = 3.37, 95{\%} CI 1.94–5.83) of hospitalization compared with survivors who received surgery and/or radiation alone. Among hospitalized survivors, the most common reason was injury for bone tumor (26.8{\%}) and neoplasm for soft tissue sarcoma (12.2{\%}). Conclusion: Childhood survivors of bone tumor and soft tissue sarcoma face ongoing risk of hospitalization for years after diagnosis.",
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