Long-term survivors in Nairobi: Complete HIV-1 RNA sequences and immunogenetic associations

Guowei Fang, Carla Kuiken, Barbara Weiser, Sarah Rowland-Jones, Francis Plummer, Chih Hsiung Chen, Rupert Kaul, Aggrey Omu Anzala, Job Bwayo, Joshua Kimani, Sean M. Philpott, Christina Kitchen, Janet S. Sinsheimer, Brian Gaschen, Dorothy Lang, Binshan Shi, Kimdar Sherefa Kemal, Tim Rostron, Cheryl Brunner, Simon BeddowsQuentin Sattenau, Ellen Paxinos, Julius Oyugi, Harold Burger

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P = .0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.

Original languageEnglish (US)
Pages (from-to)697-701
Number of pages5
JournalJournal of Infectious Diseases
Volume190
Issue number4
DOIs
StatePublished - Aug 15 2004
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Fang, G., Kuiken, C., Weiser, B., Rowland-Jones, S., Plummer, F., Chen, C. H., Kaul, R., Anzala, A. O., Bwayo, J., Kimani, J., Philpott, S. M., Kitchen, C., Sinsheimer, J. S., Gaschen, B., Lang, D., Shi, B., Kemal, K. S., Rostron, T., Brunner, C., ... Burger, H. (2004). Long-term survivors in Nairobi: Complete HIV-1 RNA sequences and immunogenetic associations. Journal of Infectious Diseases, 190(4), 697-701. https://doi.org/10.1086/421504