TY - JOUR
T1 - Long-term survivors in Nairobi
T2 - Complete HIV-1 RNA sequences and immunogenetic associations
AU - Fang, Guowei
AU - Kuiken, Carla
AU - Weiser, Barbara
AU - Rowland-Jones, Sarah
AU - Plummer, Francis
AU - Chen, Chih Hsiung
AU - Kaul, Rupert
AU - Anzala, Aggrey Omu
AU - Bwayo, Job
AU - Kimani, Joshua
AU - Philpott, Sean M.
AU - Kitchen, Christina
AU - Sinsheimer, Janet S.
AU - Gaschen, Brian
AU - Lang, Dorothy
AU - Shi, Binshan
AU - Kemal, Kimdar Sherefa
AU - Rostron, Tim
AU - Brunner, Cheryl
AU - Beddows, Simon
AU - Sattenau, Quentin
AU - Paxinos, Ellen
AU - Oyugi, Julius
AU - Burger, Harold
PY - 2004/8/15
Y1 - 2004/8/15
N2 - To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P = .0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.
AB - To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P = .0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.
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U2 - 10.1086/421504
DO - 10.1086/421504
M3 - Article
C2 - 15272396
AN - SCOPUS:3943058117
VL - 190
SP - 697
EP - 701
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -