Long-term renal function in kidney donors. Sustained compensatory hyperfiltration with no adverse effects

F. Vincenti, W. J C Amend, George Kaysen, N. Feduska, J. Birnbaum, R. Duca, O. Salvatierra

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134 Scopus citations

Abstract

Twenty patients who underwent uninephrectomy for kidney donation between 1964 and 1968 participated in a long-term study of the function of the solitary kidney. Mean follow up after uninephrectomy was 15.8 ± 3 years. One patient with a strong family history of essential hypertension developed de novo mild hypertension. The current creatinine clearance of the donors was 80 ± 4 ml/min. The 1-week, 3-6 months and 14-18 years postuninephrectomy percentages of predonation creatinine clearance were 72 ± 3%, 76 ± 3% and 78 ±2%, respectively. The 24-hr urine protein excretion in kidney donors was significantly higher than in controls (141 ± 20 mg vs. 74 ± 3 mg, respectively, P < .0005). Except for one donor who may have developed glomerulonephritis, the donors had normal urinary albumin excretion. The cause of the slightly elevated nonalbumin proteinuria is not known. However, this long-term study of kidney donors shows no adverse effects on the blood pressure and renal function after many years of compensatory hyperfiltration.

Original languageEnglish (US)
Pages (from-to)626-629
Number of pages4
JournalTransplantation
Volume36
Issue number6
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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