Long-term outcomes of angiographically confirmed coronary stent thrombosis: Results from a multicentre California registry

Khung Keong Yeo, Ehrin J. Armstrong, Krishan Soni, Stephen W. Waldo, Mitul Patel, Ryan Reeves, John S. MacGregor, Reginald Low, Kendrick A. Shunk, Ehtisham Mahmud, Jason H Rogers

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Aims: Limited data exist on long-term outcomes of patients with stent thrombosis (ST). Our aim was to describe the long-term outcomes after angiographically confirmed ST. Methods and results: In this multicentre registry, consecutive cases of definite ST were identified between 2005 and 2013. Clinical and procedural characteristics, in-hospital outcomes and long-term survival up to five years were compared between those with and those without adverse cardiovascular and cerebrovascular events (MACCE), defined as all-cause mortality, myocardial infarction and stroke. Two hundred and twentyone patients with 239 stent thrombosis events were identified. Patients who developed MACCE were older, less likely to be men, and less likely to have hypertension. Angiographic characteristics were similar. Patients who had a MACCE event showed a trend towards a lower likelihood of procedural success (86% vs. 91%, p=0.05). MACCE rates were 22% at one year and 41% at five years. All-cause mortality was 13% at one year and 24% at five years. On multivariable analysis, age, diabetes mellitus, active smoking and ST at a bifurcation were independently associated with the occurrence of MACCE up to five years. Conclusions: Age, active smoking, diabetes mellitus and bifurcation disease are independently associated with long-term MACCE over a five-year follow-up period.

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalEuroIntervention
Volume11
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • Coronary artery disease
  • Risk factors
  • Stent thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Yeo, K. K., Armstrong, E. J., Soni, K., Waldo, S. W., Patel, M., Reeves, R., MacGregor, J. S., Low, R., Shunk, K. A., Mahmud, E., & Rogers, J. H. (2015). Long-term outcomes of angiographically confirmed coronary stent thrombosis: Results from a multicentre California registry. EuroIntervention, 11(2), 188-195. https://doi.org/10.4244/EIJV11I2A33