Long-term outcomes for infants with very low risk wilms tumor treated with surgery alone in national wilms tumor study-5

Robert C. Shamberger, James R. Anderson, Norman E. Breslow, Elizabeth J. Perlman, J. Bruce Beckwith, Michael L. Ritchey, Gerald M. Haase, Milton Donaldson, Paul E. Grundy, Robert Weetman, Max J. Coppes, Marcio Malogolowkin, Patricia D. Shearer, Morris Kletzel, Patrick R M Thomas, Roger MacKlis, Vicki Huff, Douglas A. Weeks, Daniel M. Green

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the event-free survival (EFS) and overall survival (OS) of children with very low risk Wilms tumor (VLRWT) treated with surgery only. Background: Previous studies suggested that postoperative chemotherapy had not improved the prognosis of children with VLRWT. A total of 77 children <24 months of age with small (<550 g) Stage I favorable histology Wilms tumors were treated with surgery only. This study was closed based on stopping rules to ensure that the 2-year EFS was ≥90%. Methods: A total of 77 children were assessed for EFS and OS. Of these patients, 21 enrolled at the time of closure were recalled, treated with dactinomycin and vincristine (regimen EE4A), and censored for analysis thereafter. About 111 children subsequently treated with EE4A were available for comparison. Results: Median follow-up of surviving patients was 8.2 years for surgery only (range, 1.9-11.8 years) and 5.2 years for the EE4A group (range, 1.6-8.9 years). The estimated 5-year EFS for surgery only was 84% (95% confidence interval [CI]: 73%, 91%); for the EE4A patients it was 97% (95% CI: 92%, 99%, P = 0.002). One death was observed in each treatment group. The estimated 5-year OS was 98% (95% CI: 87%, 99%) for surgery only and 99% (95% CI: 94%, 99%) for EE4A (P = 0.70). Conclusion: The surgery-only EFS was lower than anticipated but, coupled with a much higher than anticipated salvage rate of the chemotherapy naive patients whose disease recurred, led to an observed long-term OS equivalent to that seen with 2-drug chemotherapy. This approach to the treatment of patients with VLRWT eliminates the toxic side-effects of chemotherapy for a large majority of patients. A follow-up study is underway to confirm these findings.

Original languageEnglish (US)
Pages (from-to)555-558
Number of pages4
JournalAnnals of Surgery
Volume251
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

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Wilms Tumor
Disease-Free Survival
Confidence Intervals
Drug Therapy
Survival
Poisons
Dactinomycin
Vincristine
Wilms tumor and radial bilateral aplasia
Histology
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery

Cite this

Shamberger, R. C., Anderson, J. R., Breslow, N. E., Perlman, E. J., Beckwith, J. B., Ritchey, M. L., ... Green, D. M. (2010). Long-term outcomes for infants with very low risk wilms tumor treated with surgery alone in national wilms tumor study-5. Annals of Surgery, 251(3), 555-558. https://doi.org/10.1097/SLA.0b013e3181c0e5d7

Long-term outcomes for infants with very low risk wilms tumor treated with surgery alone in national wilms tumor study-5. / Shamberger, Robert C.; Anderson, James R.; Breslow, Norman E.; Perlman, Elizabeth J.; Beckwith, J. Bruce; Ritchey, Michael L.; Haase, Gerald M.; Donaldson, Milton; Grundy, Paul E.; Weetman, Robert; Coppes, Max J.; Malogolowkin, Marcio; Shearer, Patricia D.; Kletzel, Morris; Thomas, Patrick R M; MacKlis, Roger; Huff, Vicki; Weeks, Douglas A.; Green, Daniel M.

In: Annals of Surgery, Vol. 251, No. 3, 01.03.2010, p. 555-558.

Research output: Contribution to journalArticle

Shamberger, RC, Anderson, JR, Breslow, NE, Perlman, EJ, Beckwith, JB, Ritchey, ML, Haase, GM, Donaldson, M, Grundy, PE, Weetman, R, Coppes, MJ, Malogolowkin, M, Shearer, PD, Kletzel, M, Thomas, PRM, MacKlis, R, Huff, V, Weeks, DA & Green, DM 2010, 'Long-term outcomes for infants with very low risk wilms tumor treated with surgery alone in national wilms tumor study-5', Annals of Surgery, vol. 251, no. 3, pp. 555-558. https://doi.org/10.1097/SLA.0b013e3181c0e5d7
Shamberger, Robert C. ; Anderson, James R. ; Breslow, Norman E. ; Perlman, Elizabeth J. ; Beckwith, J. Bruce ; Ritchey, Michael L. ; Haase, Gerald M. ; Donaldson, Milton ; Grundy, Paul E. ; Weetman, Robert ; Coppes, Max J. ; Malogolowkin, Marcio ; Shearer, Patricia D. ; Kletzel, Morris ; Thomas, Patrick R M ; MacKlis, Roger ; Huff, Vicki ; Weeks, Douglas A. ; Green, Daniel M. / Long-term outcomes for infants with very low risk wilms tumor treated with surgery alone in national wilms tumor study-5. In: Annals of Surgery. 2010 ; Vol. 251, No. 3. pp. 555-558.
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abstract = "Objective: To determine the event-free survival (EFS) and overall survival (OS) of children with very low risk Wilms tumor (VLRWT) treated with surgery only. Background: Previous studies suggested that postoperative chemotherapy had not improved the prognosis of children with VLRWT. A total of 77 children <24 months of age with small (<550 g) Stage I favorable histology Wilms tumors were treated with surgery only. This study was closed based on stopping rules to ensure that the 2-year EFS was ≥90{\%}. Methods: A total of 77 children were assessed for EFS and OS. Of these patients, 21 enrolled at the time of closure were recalled, treated with dactinomycin and vincristine (regimen EE4A), and censored for analysis thereafter. About 111 children subsequently treated with EE4A were available for comparison. Results: Median follow-up of surviving patients was 8.2 years for surgery only (range, 1.9-11.8 years) and 5.2 years for the EE4A group (range, 1.6-8.9 years). The estimated 5-year EFS for surgery only was 84{\%} (95{\%} confidence interval [CI]: 73{\%}, 91{\%}); for the EE4A patients it was 97{\%} (95{\%} CI: 92{\%}, 99{\%}, P = 0.002). One death was observed in each treatment group. The estimated 5-year OS was 98{\%} (95{\%} CI: 87{\%}, 99{\%}) for surgery only and 99{\%} (95{\%} CI: 94{\%}, 99{\%}) for EE4A (P = 0.70). Conclusion: The surgery-only EFS was lower than anticipated but, coupled with a much higher than anticipated salvage rate of the chemotherapy naive patients whose disease recurred, led to an observed long-term OS equivalent to that seen with 2-drug chemotherapy. This approach to the treatment of patients with VLRWT eliminates the toxic side-effects of chemotherapy for a large majority of patients. A follow-up study is underway to confirm these findings.",
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T1 - Long-term outcomes for infants with very low risk wilms tumor treated with surgery alone in national wilms tumor study-5

AU - Shamberger, Robert C.

AU - Anderson, James R.

AU - Breslow, Norman E.

AU - Perlman, Elizabeth J.

AU - Beckwith, J. Bruce

AU - Ritchey, Michael L.

AU - Haase, Gerald M.

AU - Donaldson, Milton

AU - Grundy, Paul E.

AU - Weetman, Robert

AU - Coppes, Max J.

AU - Malogolowkin, Marcio

AU - Shearer, Patricia D.

AU - Kletzel, Morris

AU - Thomas, Patrick R M

AU - MacKlis, Roger

AU - Huff, Vicki

AU - Weeks, Douglas A.

AU - Green, Daniel M.

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N2 - Objective: To determine the event-free survival (EFS) and overall survival (OS) of children with very low risk Wilms tumor (VLRWT) treated with surgery only. Background: Previous studies suggested that postoperative chemotherapy had not improved the prognosis of children with VLRWT. A total of 77 children <24 months of age with small (<550 g) Stage I favorable histology Wilms tumors were treated with surgery only. This study was closed based on stopping rules to ensure that the 2-year EFS was ≥90%. Methods: A total of 77 children were assessed for EFS and OS. Of these patients, 21 enrolled at the time of closure were recalled, treated with dactinomycin and vincristine (regimen EE4A), and censored for analysis thereafter. About 111 children subsequently treated with EE4A were available for comparison. Results: Median follow-up of surviving patients was 8.2 years for surgery only (range, 1.9-11.8 years) and 5.2 years for the EE4A group (range, 1.6-8.9 years). The estimated 5-year EFS for surgery only was 84% (95% confidence interval [CI]: 73%, 91%); for the EE4A patients it was 97% (95% CI: 92%, 99%, P = 0.002). One death was observed in each treatment group. The estimated 5-year OS was 98% (95% CI: 87%, 99%) for surgery only and 99% (95% CI: 94%, 99%) for EE4A (P = 0.70). Conclusion: The surgery-only EFS was lower than anticipated but, coupled with a much higher than anticipated salvage rate of the chemotherapy naive patients whose disease recurred, led to an observed long-term OS equivalent to that seen with 2-drug chemotherapy. This approach to the treatment of patients with VLRWT eliminates the toxic side-effects of chemotherapy for a large majority of patients. A follow-up study is underway to confirm these findings.

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