Long-term outcome in children after Henoch-Schönlein purpura nephritis

Lavjay Butani, Bruce Z. Morgenstern

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

This study investigated predictors of renal survival in children with Henoch-Schönlein purpura glomerulonephritis. Records of patients with Henoch-Schönlein purpura glomerulonephritis evaluated at our center, from 1953-1990, were reviewed. Data were abstracted from records of patients seen within 5 years. Others were mailed a questionnaire or contacted by telephone. Primary outcome measures were renal survival and presence of urinary abnormalities or hypertension. Of the 65 eligible patients with Henoch Schönlein purpura glomerulonephritis, follow-up data was obtainable for 81.5%. The median follow-up was 20 years. At last follow-up, 66% of patients had normal renal function and urinalyses, and 21% had progressed to end-stage renal disease. The only factor associated with the development of end-stage renal disease was the use of cytotoxic agents. There are no features at initial presentation that identify children at risk of disease progression. Close follow-up of all children with Henoch Schönlein purpura glomerulonephritis is warranted.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalClinical Pediatrics
Volume46
Issue number6
DOIs
StatePublished - Jul 2007

Keywords

  • End-stage renal disease
  • Glomerulonephritis
  • Henoch-Schönlein purpura
  • Hypertension
  • Outcome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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