Long-term marginal zinc deprivation in rhesus monkeys. II. Effects on maternal health and fetal growth at midgestation

D. C. Haynes, M. S. Golub, M. E. Gershwin, L. S. Hurley, A. G. Hendrickx

Research output: Contribution to journalArticle

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Abstract

Adult nonpregnant female rhesus monkeys fed purified diets containing 100 or 4 ppm zinc for 1 yr were mated then studied through midgestation. At mating, zinc-deprived (ZD) monkeys showed maternal lymphocyte response to mitogens concanavalin A (Con A) and phytohemagglutinin (PHA), serum uric acid and carbon dioxide, and WBC lower than in control (C) monkeys. There was a significant positive association between plasma zinc and PHA response. At midgestation, discriminant analysis revealed that maternal lymphocyte response to Con A, fetal abdominal circumference (by ultrasound), plasma fibrinogen, serum IgM, and amniotic fluid iron level discriminators for diet group, all lower in ZD than in C monkeys. Maternal plasma and RBC zinc at midgestation were positively associated with fetal growth and plasma uric acid. These observations suggest that immune function (ie, mitogen response and serum immunoglobulin level) is a strong discriminator of dietary zinc deprivation in rhesus monkeys, both before and during pregnancy.

Original languageEnglish (US)
Pages (from-to)1503-1513
Number of pages11
JournalAmerican Journal of Clinical Nutrition
Volume45
Issue number6
StatePublished - 1987

Fingerprint

fetal development
Fetal Development
Macaca mulatta
Zinc
zinc
blood serum
Haplorhini
monkeys
phytohemagglutinin
Mothers
Phytohemagglutinins
uric acid
concanavalin A
Concanavalin A
Uric Acid
Mitogens
lymphocytes
Serum
Lymphocytes
Diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Long-term marginal zinc deprivation in rhesus monkeys. II. Effects on maternal health and fetal growth at midgestation. / Haynes, D. C.; Golub, M. S.; Gershwin, M. E.; Hurley, L. S.; Hendrickx, A. G.

In: American Journal of Clinical Nutrition, Vol. 45, No. 6, 1987, p. 1503-1513.

Research output: Contribution to journalArticle

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AU - Hendrickx, A. G.

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