Long-term marginal zinc deprivation in rhesus monkeys. I. Effects on adult female breeders before conception

D. C. Haynes, M. S. Golub, M. E. Gershwin, A. T. Cheung, L. S. Hurley, A. G. Hendrickx

Research output: Contribution to journalArticle

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Abstract

To assess long-term effects of marginal zinc deprivation on pregnancy, adult nonpregnant female rhesus monkeys were fed diets containing 100 or 4 ppm zinc for 1 yr, then mated; effects on pregnancy and its outcome are under study. During this year, food intake was not depressed in zinc-deprived (ZD) monkeys, and there were relatively few effects on biochemical or hematological indices. By the end of the year, plasma zinc concentration was somewhat lower in ZD monkeys than in controls. Several immune variables, including serum IgM and IgG levels and polymorphonuclear leukocytes (PMN) function, were depressed in the ZD group, changes closely reflecting circannual fluctuations in plasma zinc levels in both diet groups. Endotoxin-activated plasma from ZD monkeys had less potential to promote chemotaxis than that from control monkeys, suggesting that defective PMN function may relate to a plasma effect. Marginal zinc deprivation may thus influence immune function before other variables are affected.

Original languageEnglish (US)
Pages (from-to)1492-1502
Number of pages11
JournalAmerican Journal of Clinical Nutrition
Volume45
Issue number6
StatePublished - 1987

Fingerprint

Macaca mulatta
Zinc
zinc
Haplorhini
monkeys
neutrophils
Neutrophils
pregnancy
Diet
chemotaxis
Chemotaxis
Pregnancy Outcome
endotoxins
Endotoxins
diet
Immunoglobulin M
long term effects
food intake
Eating
Immunoglobulin G

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Long-term marginal zinc deprivation in rhesus monkeys. I. Effects on adult female breeders before conception. / Haynes, D. C.; Golub, M. S.; Gershwin, M. E.; Cheung, A. T.; Hurley, L. S.; Hendrickx, A. G.

In: American Journal of Clinical Nutrition, Vol. 45, No. 6, 1987, p. 1492-1502.

Research output: Contribution to journalArticle

Haynes, D. C. ; Golub, M. S. ; Gershwin, M. E. ; Cheung, A. T. ; Hurley, L. S. ; Hendrickx, A. G. / Long-term marginal zinc deprivation in rhesus monkeys. I. Effects on adult female breeders before conception. In: American Journal of Clinical Nutrition. 1987 ; Vol. 45, No. 6. pp. 1492-1502.
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