Long-term management of copper-associated hepatic cirrhosis with D-penicillamine, SAMe, and DBB in a dog

Kyoung Won Seo, Young Heun Lee, Dong Ha Bhang, Jin ok Ahn, Ye rin Coh, Cheol young Hwang, Dea yong Kim, Hwa young Youn

Research output: Contribution to journalArticle

Abstract

A 4-year-old intact female American Cocker Spaniel presented with lack of appetite, shivering, and abdominal distension. It was initially diagnosed with chronic hepatitis with cirrhosis, by serum chemistry, radiography, ultrasonography, and histopathologic examination following liver biopsy. Abundant copper granules were detected in most hepatocytes with rhodanine stain, with hepatic copper concentration at 1460 ppm (reference range: <400ppm). Based on these findings, copper-associated hepatitis with cirrhosis was diagnosed and successfully managed with long- term D-penicillamine, s-adenosylmethionine, biphenyl-dimethyl-dicarboxylate and supportive care. The spaniel died 35 months after diagnosis.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalJournal of Veterinary Clinics
Volume28
Issue number2
StatePublished - Aug 15 2011
Externally publishedYes

Keywords

  • American Cocker Spaniel
  • Canine
  • Copper-associated hepatopathy
  • Hepatic cirrhosis

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Seo, K. W., Lee, Y. H., Bhang, D. H., Ahn, J. O., Coh, Y. R., Hwang, C. Y., Kim, D. Y., & Youn, H. Y. (2011). Long-term management of copper-associated hepatic cirrhosis with D-penicillamine, SAMe, and DBB in a dog. Journal of Veterinary Clinics, 28(2), 249-253.