Long-term haematological changes in cats experimentally infected with feline immunodeficiency virus (FIV)

Carol P. Mandell, E. Elizabeth Sparger, Niels C Pedersen, N. C. Jain

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Haematological changes of experimental feline immunodeficiency virus (FIV) infection in six inoculated and six control cats were studied over a 98 week period. Acute infection was characterised by moderate to severe leucopenia, neutropenia, and eosinopenia between weeks 5 and 13 post-inoculation (PI). Normal myeloid activity or mild myeloid hyperplasia with a left shift to promyelocytes accompanied neutropenia. Chronic infection was characterised by intermittent neutropenia in three of six cats beginning after week 50 Pl and lymphopenia in two cats starting on week 66 Pl. The severity and duration of neutropenia and lymphopenia varied in individual cats. In contrast to natural FIV infections, anaemia and thrombocytopenia did not develop in either acute or chronic experimental infection. Age-related haematological changes such as increasing packed cell volume and plasma protein concentration as well as decreasing neutrophil and total leucocyte counts were noted as both control and inoculated cats reached maturity. The mechanisms of neutropenia and eosinopenia remain unknown. Viral infection of myeloid cells may be involved in the pathogenesis of cytopenias, and further studies are needed to elucidate the mechanisms. This study also demonstrated that FIV infection in cats may be a useful model in studying haematological abnormalities associated with other immunodeficiency-causing lentiviruses.

Original languageEnglish (US)
Pages (from-to)8-17
Number of pages10
JournalComparative Haematology International
Volume2
Issue number1
DOIs
StatePublished - Feb 1992

Fingerprint

Feline Immunodeficiency Virus
Neutropenia
Cats
Virus Diseases
Lymphopenia
Infection
Granulocyte Precursor Cells
Lentivirus
Leukopenia
Myeloid Cells
Leukocyte Count
Cell Size
Thrombocytopenia
Hyperplasia
Anemia
Blood Proteins
Neutrophils

Keywords

  • Cats
  • Feline immunodeficiency virus
  • Haematology
  • Lymphopenia
  • Neutropenia

ASJC Scopus subject areas

  • Hematology

Cite this

Long-term haematological changes in cats experimentally infected with feline immunodeficiency virus (FIV). / Mandell, Carol P.; Sparger, E. Elizabeth; Pedersen, Niels C; Jain, N. C.

In: Comparative Haematology International, Vol. 2, No. 1, 02.1992, p. 8-17.

Research output: Contribution to journalArticle

@article{f2dbed9b86a7426c98f020bf8c6237c7,
title = "Long-term haematological changes in cats experimentally infected with feline immunodeficiency virus (FIV)",
abstract = "Haematological changes of experimental feline immunodeficiency virus (FIV) infection in six inoculated and six control cats were studied over a 98 week period. Acute infection was characterised by moderate to severe leucopenia, neutropenia, and eosinopenia between weeks 5 and 13 post-inoculation (PI). Normal myeloid activity or mild myeloid hyperplasia with a left shift to promyelocytes accompanied neutropenia. Chronic infection was characterised by intermittent neutropenia in three of six cats beginning after week 50 Pl and lymphopenia in two cats starting on week 66 Pl. The severity and duration of neutropenia and lymphopenia varied in individual cats. In contrast to natural FIV infections, anaemia and thrombocytopenia did not develop in either acute or chronic experimental infection. Age-related haematological changes such as increasing packed cell volume and plasma protein concentration as well as decreasing neutrophil and total leucocyte counts were noted as both control and inoculated cats reached maturity. The mechanisms of neutropenia and eosinopenia remain unknown. Viral infection of myeloid cells may be involved in the pathogenesis of cytopenias, and further studies are needed to elucidate the mechanisms. This study also demonstrated that FIV infection in cats may be a useful model in studying haematological abnormalities associated with other immunodeficiency-causing lentiviruses.",
keywords = "Cats, Feline immunodeficiency virus, Haematology, Lymphopenia, Neutropenia",
author = "Mandell, {Carol P.} and Sparger, {E. Elizabeth} and Pedersen, {Niels C} and Jain, {N. C.}",
year = "1992",
month = "2",
doi = "10.1007/BF02984520",
language = "English (US)",
volume = "2",
pages = "8--17",
journal = "Comparative Clinical Pathology",
issn = "1618-5641",
publisher = "Springer London",
number = "1",

}

TY - JOUR

T1 - Long-term haematological changes in cats experimentally infected with feline immunodeficiency virus (FIV)

AU - Mandell, Carol P.

AU - Sparger, E. Elizabeth

AU - Pedersen, Niels C

AU - Jain, N. C.

PY - 1992/2

Y1 - 1992/2

N2 - Haematological changes of experimental feline immunodeficiency virus (FIV) infection in six inoculated and six control cats were studied over a 98 week period. Acute infection was characterised by moderate to severe leucopenia, neutropenia, and eosinopenia between weeks 5 and 13 post-inoculation (PI). Normal myeloid activity or mild myeloid hyperplasia with a left shift to promyelocytes accompanied neutropenia. Chronic infection was characterised by intermittent neutropenia in three of six cats beginning after week 50 Pl and lymphopenia in two cats starting on week 66 Pl. The severity and duration of neutropenia and lymphopenia varied in individual cats. In contrast to natural FIV infections, anaemia and thrombocytopenia did not develop in either acute or chronic experimental infection. Age-related haematological changes such as increasing packed cell volume and plasma protein concentration as well as decreasing neutrophil and total leucocyte counts were noted as both control and inoculated cats reached maturity. The mechanisms of neutropenia and eosinopenia remain unknown. Viral infection of myeloid cells may be involved in the pathogenesis of cytopenias, and further studies are needed to elucidate the mechanisms. This study also demonstrated that FIV infection in cats may be a useful model in studying haematological abnormalities associated with other immunodeficiency-causing lentiviruses.

AB - Haematological changes of experimental feline immunodeficiency virus (FIV) infection in six inoculated and six control cats were studied over a 98 week period. Acute infection was characterised by moderate to severe leucopenia, neutropenia, and eosinopenia between weeks 5 and 13 post-inoculation (PI). Normal myeloid activity or mild myeloid hyperplasia with a left shift to promyelocytes accompanied neutropenia. Chronic infection was characterised by intermittent neutropenia in three of six cats beginning after week 50 Pl and lymphopenia in two cats starting on week 66 Pl. The severity and duration of neutropenia and lymphopenia varied in individual cats. In contrast to natural FIV infections, anaemia and thrombocytopenia did not develop in either acute or chronic experimental infection. Age-related haematological changes such as increasing packed cell volume and plasma protein concentration as well as decreasing neutrophil and total leucocyte counts were noted as both control and inoculated cats reached maturity. The mechanisms of neutropenia and eosinopenia remain unknown. Viral infection of myeloid cells may be involved in the pathogenesis of cytopenias, and further studies are needed to elucidate the mechanisms. This study also demonstrated that FIV infection in cats may be a useful model in studying haematological abnormalities associated with other immunodeficiency-causing lentiviruses.

KW - Cats

KW - Feline immunodeficiency virus

KW - Haematology

KW - Lymphopenia

KW - Neutropenia

UR - http://www.scopus.com/inward/record.url?scp=0008098130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0008098130&partnerID=8YFLogxK

U2 - 10.1007/BF02984520

DO - 10.1007/BF02984520

M3 - Article

AN - SCOPUS:0008098130

VL - 2

SP - 8

EP - 17

JO - Comparative Clinical Pathology

JF - Comparative Clinical Pathology

SN - 1618-5641

IS - 1

ER -