Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia

Michael B. Chancellor, Jerzy Gajewski, C. F Douglas Ackman, Rodney A. Appell, James Bennett, Joseph Binard, Timothy B. Boone, Michael P. Chetner, Julie Ann Crewalk, Alfred Defalco, Jenelle Foote, Bruce Green, Saad Juma, Suk Young Jung, Todd A. Linsenmeyer, Robert Macmillan, Michael Mayo, Hideo Ozawa, Claus G. Roehrborn, Patrick J. ShenotAnthony R Stone, Albert Vazquez, Wylly Killorin, David A. Rivas

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Purpose: We determine the long-term efficacy and safety of the UroLume stent as minimally invasive treatment for external detrusor-sphincter dyssynergia in spinal cord injured men. Materials and Methods: A total of 160 spinal cord injured men with a mean age plus or minus standard deviation of 36.3 ± 12.1 years (range 16 to 74) were prospectively treated with an endoprosthesis at 15 centers as part of the North American UroLume trial for external detrusor-sphincter dyssynergia. Urodynamic parameters, including voiding pressure, residual urine volume and bladder capacity, were compared before treatment and at 1, 2, 3, 4 and 5 years after treatment. Results: Mean voiding pressure was 75.1 ± 28.2 cm. water before treatment in the 160 patients, and 37.4 ± 23.9 at year 1 in 97, 39.5 ± 22.2 at year 2 in 84, 42.6 ± 27.3 at year 3 in 61, 46.3 ± 33.2 at year 4 in 57 and 44.2 ± 28.9 cm. at year 5 in 41 after stent insertion (p <0.001). Residual urine volume decreased after stent placement and was maintained throughout the 5-year followup (p <0.001). Mean cystometric capacity remained constant from 269 ± 155 before insertion to 337 ± 182 ml. 5 years later (p = 0.17). Hydronephrosis and autonomic dysreflexia improved or stabilized in most patients with functioning stents. Stent explant was necessary in 24 patients (15%), of whom 4 (16.7%) had another stent implanted. Conclusions: The UroLume stent demonstrates long-term safety and efficacy for the treatment of external detrusor-sphincter dyssynergia. The outcome was similar in men with and without previous sphincterotomy.

Original languageEnglish (US)
Pages (from-to)1545-1550
Number of pages6
JournalJournal of Urology
Volume161
Issue number5
DOIs
StatePublished - May 1999

Fingerprint

Ataxia
Multicenter Studies
Stents
Residual Volume
Therapeutics
Spinal Cord
Autonomic Dysreflexia
Urine
Safety
Pressure
Hydronephrosis
Water Purification
Urodynamics
Urinary Bladder

Keywords

  • Spinal cord injuries
  • Stents
  • Urinary incontinence
  • Urinary tract infections
  • Urodynamics

ASJC Scopus subject areas

  • Urology

Cite this

Chancellor, M. B., Gajewski, J., Ackman, C. F. D., Appell, R. A., Bennett, J., Binard, J., ... Rivas, D. A. (1999). Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia. Journal of Urology, 161(5), 1545-1550. https://doi.org/10.1016/S0022-5347(05)68950-1

Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia. / Chancellor, Michael B.; Gajewski, Jerzy; Ackman, C. F Douglas; Appell, Rodney A.; Bennett, James; Binard, Joseph; Boone, Timothy B.; Chetner, Michael P.; Crewalk, Julie Ann; Defalco, Alfred; Foote, Jenelle; Green, Bruce; Juma, Saad; Jung, Suk Young; Linsenmeyer, Todd A.; Macmillan, Robert; Mayo, Michael; Ozawa, Hideo; Roehrborn, Claus G.; Shenot, Patrick J.; Stone, Anthony R; Vazquez, Albert; Killorin, Wylly; Rivas, David A.

In: Journal of Urology, Vol. 161, No. 5, 05.1999, p. 1545-1550.

Research output: Contribution to journalArticle

Chancellor, MB, Gajewski, J, Ackman, CFD, Appell, RA, Bennett, J, Binard, J, Boone, TB, Chetner, MP, Crewalk, JA, Defalco, A, Foote, J, Green, B, Juma, S, Jung, SY, Linsenmeyer, TA, Macmillan, R, Mayo, M, Ozawa, H, Roehrborn, CG, Shenot, PJ, Stone, AR, Vazquez, A, Killorin, W & Rivas, DA 1999, 'Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia', Journal of Urology, vol. 161, no. 5, pp. 1545-1550. https://doi.org/10.1016/S0022-5347(05)68950-1
Chancellor, Michael B. ; Gajewski, Jerzy ; Ackman, C. F Douglas ; Appell, Rodney A. ; Bennett, James ; Binard, Joseph ; Boone, Timothy B. ; Chetner, Michael P. ; Crewalk, Julie Ann ; Defalco, Alfred ; Foote, Jenelle ; Green, Bruce ; Juma, Saad ; Jung, Suk Young ; Linsenmeyer, Todd A. ; Macmillan, Robert ; Mayo, Michael ; Ozawa, Hideo ; Roehrborn, Claus G. ; Shenot, Patrick J. ; Stone, Anthony R ; Vazquez, Albert ; Killorin, Wylly ; Rivas, David A. / Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia. In: Journal of Urology. 1999 ; Vol. 161, No. 5. pp. 1545-1550.
@article{1d428bb32712464399a19ae50267452e,
title = "Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia",
abstract = "Purpose: We determine the long-term efficacy and safety of the UroLume stent as minimally invasive treatment for external detrusor-sphincter dyssynergia in spinal cord injured men. Materials and Methods: A total of 160 spinal cord injured men with a mean age plus or minus standard deviation of 36.3 ± 12.1 years (range 16 to 74) were prospectively treated with an endoprosthesis at 15 centers as part of the North American UroLume trial for external detrusor-sphincter dyssynergia. Urodynamic parameters, including voiding pressure, residual urine volume and bladder capacity, were compared before treatment and at 1, 2, 3, 4 and 5 years after treatment. Results: Mean voiding pressure was 75.1 ± 28.2 cm. water before treatment in the 160 patients, and 37.4 ± 23.9 at year 1 in 97, 39.5 ± 22.2 at year 2 in 84, 42.6 ± 27.3 at year 3 in 61, 46.3 ± 33.2 at year 4 in 57 and 44.2 ± 28.9 cm. at year 5 in 41 after stent insertion (p <0.001). Residual urine volume decreased after stent placement and was maintained throughout the 5-year followup (p <0.001). Mean cystometric capacity remained constant from 269 ± 155 before insertion to 337 ± 182 ml. 5 years later (p = 0.17). Hydronephrosis and autonomic dysreflexia improved or stabilized in most patients with functioning stents. Stent explant was necessary in 24 patients (15{\%}), of whom 4 (16.7{\%}) had another stent implanted. Conclusions: The UroLume stent demonstrates long-term safety and efficacy for the treatment of external detrusor-sphincter dyssynergia. The outcome was similar in men with and without previous sphincterotomy.",
keywords = "Spinal cord injuries, Stents, Urinary incontinence, Urinary tract infections, Urodynamics",
author = "Chancellor, {Michael B.} and Jerzy Gajewski and Ackman, {C. F Douglas} and Appell, {Rodney A.} and James Bennett and Joseph Binard and Boone, {Timothy B.} and Chetner, {Michael P.} and Crewalk, {Julie Ann} and Alfred Defalco and Jenelle Foote and Bruce Green and Saad Juma and Jung, {Suk Young} and Linsenmeyer, {Todd A.} and Robert Macmillan and Michael Mayo and Hideo Ozawa and Roehrborn, {Claus G.} and Shenot, {Patrick J.} and Stone, {Anthony R} and Albert Vazquez and Wylly Killorin and Rivas, {David A.}",
year = "1999",
month = "5",
doi = "10.1016/S0022-5347(05)68950-1",
language = "English (US)",
volume = "161",
pages = "1545--1550",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia

AU - Chancellor, Michael B.

AU - Gajewski, Jerzy

AU - Ackman, C. F Douglas

AU - Appell, Rodney A.

AU - Bennett, James

AU - Binard, Joseph

AU - Boone, Timothy B.

AU - Chetner, Michael P.

AU - Crewalk, Julie Ann

AU - Defalco, Alfred

AU - Foote, Jenelle

AU - Green, Bruce

AU - Juma, Saad

AU - Jung, Suk Young

AU - Linsenmeyer, Todd A.

AU - Macmillan, Robert

AU - Mayo, Michael

AU - Ozawa, Hideo

AU - Roehrborn, Claus G.

AU - Shenot, Patrick J.

AU - Stone, Anthony R

AU - Vazquez, Albert

AU - Killorin, Wylly

AU - Rivas, David A.

PY - 1999/5

Y1 - 1999/5

N2 - Purpose: We determine the long-term efficacy and safety of the UroLume stent as minimally invasive treatment for external detrusor-sphincter dyssynergia in spinal cord injured men. Materials and Methods: A total of 160 spinal cord injured men with a mean age plus or minus standard deviation of 36.3 ± 12.1 years (range 16 to 74) were prospectively treated with an endoprosthesis at 15 centers as part of the North American UroLume trial for external detrusor-sphincter dyssynergia. Urodynamic parameters, including voiding pressure, residual urine volume and bladder capacity, were compared before treatment and at 1, 2, 3, 4 and 5 years after treatment. Results: Mean voiding pressure was 75.1 ± 28.2 cm. water before treatment in the 160 patients, and 37.4 ± 23.9 at year 1 in 97, 39.5 ± 22.2 at year 2 in 84, 42.6 ± 27.3 at year 3 in 61, 46.3 ± 33.2 at year 4 in 57 and 44.2 ± 28.9 cm. at year 5 in 41 after stent insertion (p <0.001). Residual urine volume decreased after stent placement and was maintained throughout the 5-year followup (p <0.001). Mean cystometric capacity remained constant from 269 ± 155 before insertion to 337 ± 182 ml. 5 years later (p = 0.17). Hydronephrosis and autonomic dysreflexia improved or stabilized in most patients with functioning stents. Stent explant was necessary in 24 patients (15%), of whom 4 (16.7%) had another stent implanted. Conclusions: The UroLume stent demonstrates long-term safety and efficacy for the treatment of external detrusor-sphincter dyssynergia. The outcome was similar in men with and without previous sphincterotomy.

AB - Purpose: We determine the long-term efficacy and safety of the UroLume stent as minimally invasive treatment for external detrusor-sphincter dyssynergia in spinal cord injured men. Materials and Methods: A total of 160 spinal cord injured men with a mean age plus or minus standard deviation of 36.3 ± 12.1 years (range 16 to 74) were prospectively treated with an endoprosthesis at 15 centers as part of the North American UroLume trial for external detrusor-sphincter dyssynergia. Urodynamic parameters, including voiding pressure, residual urine volume and bladder capacity, were compared before treatment and at 1, 2, 3, 4 and 5 years after treatment. Results: Mean voiding pressure was 75.1 ± 28.2 cm. water before treatment in the 160 patients, and 37.4 ± 23.9 at year 1 in 97, 39.5 ± 22.2 at year 2 in 84, 42.6 ± 27.3 at year 3 in 61, 46.3 ± 33.2 at year 4 in 57 and 44.2 ± 28.9 cm. at year 5 in 41 after stent insertion (p <0.001). Residual urine volume decreased after stent placement and was maintained throughout the 5-year followup (p <0.001). Mean cystometric capacity remained constant from 269 ± 155 before insertion to 337 ± 182 ml. 5 years later (p = 0.17). Hydronephrosis and autonomic dysreflexia improved or stabilized in most patients with functioning stents. Stent explant was necessary in 24 patients (15%), of whom 4 (16.7%) had another stent implanted. Conclusions: The UroLume stent demonstrates long-term safety and efficacy for the treatment of external detrusor-sphincter dyssynergia. The outcome was similar in men with and without previous sphincterotomy.

KW - Spinal cord injuries

KW - Stents

KW - Urinary incontinence

KW - Urinary tract infections

KW - Urodynamics

UR - http://www.scopus.com/inward/record.url?scp=0032851921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032851921&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(05)68950-1

DO - 10.1016/S0022-5347(05)68950-1

M3 - Article

C2 - 10210393

AN - SCOPUS:0032851921

VL - 161

SP - 1545

EP - 1550

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 5

ER -