Long-term effects of western diet consumption in male and female mice

Yu Hasegawa, Shin Yu Chen, Lili Sheng, Prasant Kumar Jena, Karen M. Kalanetra, David A. Mills, Yu Jui Yvonne Wan, Carolyn M. Slupsky

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Long-term consumption of a diet with excessive fat and sucrose (Western diet, WD) leads to an elevated risk of obesity and metabolic syndrome in both males and females. However, there are sexual dimorphisms in metabolism which are apparent when considering the prevalence of complications of metabolic syndrome, such as non-alcoholic fatty liver disease. This study aimed to elucidate the impact of a WD on the metabolome and the gut microbiota of male and female mice at 5, 10, and 15 months to capture the dynamic and comprehensive changes brought about by diet at different stages of life. Here we show that there are important considerations of age and sex that should be considered when assessing the impact of diet on the gut microbiome and health.

Original languageEnglish (US)
Article number14686
JournalScientific reports
Issue number1
StatePublished - Dec 1 2020

ASJC Scopus subject areas

  • General


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