Abstract
High-resolution computed tomographic (CT) scanning of the brain was performed on three groups of rhesus monkeys for the detection of ventricular or cisternal enlargement. These three groups comprised four age-matched controls that had no prior drug usage-four monkeys receiving short-term (two to ten months) orally administered delta-9-tetrahydrocannabinol (Δ9-THC [now known nonproprietarily as dronabinol]) and four monkeys receiving long-term (five years) orally administered Δ9-THC. Our results show a statistically significant enlargement of the frontal horns and the bicaudate distance in the long-term group as compared with the control and less significant enlargement of these areas in the long-term group compared with the short-term group. These findings suggest atrophy of the head of the caudate nucleus and the frontal portion of the brain of rhesus monkeys receiving long-term treatment with Δ9-THC.
Original language | English (US) |
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Pages (from-to) | 1109-1112 |
Number of pages | 4 |
Journal | American Journal of Diseases of Children |
Volume | 138 |
Issue number | 12 |
State | Published - 1984 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health