Long-term delta-9-tetrahydrocannabinol treatment. Computed tomography of the brains of rhesus monkeys

John P McGahan, A. B. Dublin, E. Sassenrath

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

High-resolution computed tomographic (CT) scanning of the brain was performed on three groups of rhesus monkeys for the detection of ventricular or cisternal enlargement. These three groups comprised four age-matched controls that had no prior drug usage-four monkeys receiving short-term (two to ten months) orally administered delta-9-tetrahydrocannabinol (Δ9-THC [now known nonproprietarily as dronabinol]) and four monkeys receiving long-term (five years) orally administered Δ9-THC. Our results show a statistically significant enlargement of the frontal horns and the bicaudate distance in the long-term group as compared with the control and less significant enlargement of these areas in the long-term group compared with the short-term group. These findings suggest atrophy of the head of the caudate nucleus and the frontal portion of the brain of rhesus monkeys receiving long-term treatment with Δ9-THC.

Original languageEnglish (US)
Pages (from-to)1109-1112
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume138
Issue number12
StatePublished - 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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