Abstract
High-resolution computed tomographic (CT) scanning of the brain was performed on three groups of rhesus monkeys for the detection of ventricular or cisternal enlargement. These three groups comprised four age-matched controls that had no prior drug usage-four monkeys receiving short-term (two to ten months) orally administered delta-9-tetrahydrocannabinol (Δ9-THC [now known nonproprietarily as dronabinol]) and four monkeys receiving long-term (five years) orally administered Δ9-THC. Our results show a statistically significant enlargement of the frontal horns and the bicaudate distance in the long-term group as compared with the control and less significant enlargement of these areas in the long-term group compared with the short-term group. These findings suggest atrophy of the head of the caudate nucleus and the frontal portion of the brain of rhesus monkeys receiving long-term treatment with Δ9-THC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1109-1112 |
| Number of pages | 4 |
| Journal | American Journal of Diseases of Children |
| Volume | 138 |
| Issue number | 12 |
| State | Published - 1984 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Long-term delta-9-tetrahydrocannabinol treatment. Computed tomography of the brains of rhesus monkeys. / McGahan, John P; Dublin, A. B.; Sassenrath, E.
In: American Journal of Diseases of Children, Vol. 138, No. 12, 1984, p. 1109-1112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term delta-9-tetrahydrocannabinol treatment. Computed tomography of the brains of rhesus monkeys
AU - McGahan, John P
AU - Dublin, A. B.
AU - Sassenrath, E.
PY - 1984
Y1 - 1984
N2 - High-resolution computed tomographic (CT) scanning of the brain was performed on three groups of rhesus monkeys for the detection of ventricular or cisternal enlargement. These three groups comprised four age-matched controls that had no prior drug usage-four monkeys receiving short-term (two to ten months) orally administered delta-9-tetrahydrocannabinol (Δ9-THC [now known nonproprietarily as dronabinol]) and four monkeys receiving long-term (five years) orally administered Δ9-THC. Our results show a statistically significant enlargement of the frontal horns and the bicaudate distance in the long-term group as compared with the control and less significant enlargement of these areas in the long-term group compared with the short-term group. These findings suggest atrophy of the head of the caudate nucleus and the frontal portion of the brain of rhesus monkeys receiving long-term treatment with Δ9-THC.
AB - High-resolution computed tomographic (CT) scanning of the brain was performed on three groups of rhesus monkeys for the detection of ventricular or cisternal enlargement. These three groups comprised four age-matched controls that had no prior drug usage-four monkeys receiving short-term (two to ten months) orally administered delta-9-tetrahydrocannabinol (Δ9-THC [now known nonproprietarily as dronabinol]) and four monkeys receiving long-term (five years) orally administered Δ9-THC. Our results show a statistically significant enlargement of the frontal horns and the bicaudate distance in the long-term group as compared with the control and less significant enlargement of these areas in the long-term group compared with the short-term group. These findings suggest atrophy of the head of the caudate nucleus and the frontal portion of the brain of rhesus monkeys receiving long-term treatment with Δ9-THC.
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M3 - Article
VL - 138
SP - 1109
EP - 1112
JO - JAMA Pediatrics
JF - JAMA Pediatrics
SN - 2168-6203
IS - 12
ER -