Long-term consequences of exposure to ozone. I. Lung collagen content

Jerold A Last, K. M. Reiser, W. S. Tyler, R. B. Rucker

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Lung collagen content of rats and monkeys (Macaca fascicularis) exposed to ozone for 1 to 13 weeks and for 1 year, respectively, was quantified by measurement of 4-hydroxyproline in hydrolysates of whole lungs. In addition, ratios of type I to type III collagen in the lungs of the same monkeys were also evaluated by cyanogen bromide peptide mapping techniques. We observed elevated levels of collagen in lungs of both species of animals exposed to ozone. We conclude that elevations in collagen synthesis rates in lungs of rats and monkeys acutely exposed to high levels of ozone are reflected by corresponding increases in lung collagen content over subchronic and chronic time frames. Preliminary results on young rats also suggest that removal of rats from atmospheres containing ozone does not cause reversal of such increases in lung collagen content. To the contrary, recovery periods of up to 6 weeks seem to exacerbate the observed increases in lung collagen content.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalToxicology and Applied Pharmacology
Volume72
Issue number1
DOIs
StatePublished - 1984

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Ozone
Collagen
Lung
Rats
Haplorhini
Cyanogen Bromide
Collagen Type III
Hydroxyproline
Peptide Mapping
Macaca fascicularis
Animals
Atmosphere
Recovery
Peptides

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Long-term consequences of exposure to ozone. I. Lung collagen content. / Last, Jerold A; Reiser, K. M.; Tyler, W. S.; Rucker, R. B.

In: Toxicology and Applied Pharmacology, Vol. 72, No. 1, 1984, p. 111-118.

Research output: Contribution to journalArticle

Last, Jerold A ; Reiser, K. M. ; Tyler, W. S. ; Rucker, R. B. / Long-term consequences of exposure to ozone. I. Lung collagen content. In: Toxicology and Applied Pharmacology. 1984 ; Vol. 72, No. 1. pp. 111-118.
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