Long-range restriction site mapping of a syntenic segment conserved between human chromosome 1 and mouse chromosome 3

Stephen F. Kingsmore, Walton S. Moseley, Mark L. Watson, Richard L. Sabina, Edward W. Holmes, Michael F Seldin

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

A linkage map determined from segregation analysis of 338 meiotic events in an interspecific mouse cross was utilized to help investigate genomic organization of a linkage group conserved between human chromosome 1p and mouse chromosome 3. Using pulsedfield gel electrophoresis, the genes encoding the lymphocyte adhesion molecule human CD2/murine Ly-37, the α1-subunit of Na, K-ATPase, the β-subunit of thyrotropin, the β-subunit of nerve growth factor, and muscle adenylate deaminase were similarly positioned on long-range restriction maps in both species. These studies indicate that the development of detailed genetic maps using interspecific Mus crosses facilitates rapid analysis of murine genomic organization and may enable physical mapping of syntenic regions within the human genome. Moreover, the data suggest profound conservation of genomic organization during mammalian evolution.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalGenomics
Volume7
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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