Abstract
A linkage map determined from segregation analysis of 338 meiotic events in an interspecific mouse cross was utilized to help investigate genomic organization of a linkage group conserved between human chromosome 1p and mouse chromosome 3. Using pulsedfield gel electrophoresis, the genes encoding the lymphocyte adhesion molecule human CD2/murine Ly-37, the α1-subunit of Na, K-ATPase, the β-subunit of thyrotropin, the β-subunit of nerve growth factor, and muscle adenylate deaminase were similarly positioned on long-range restriction maps in both species. These studies indicate that the development of detailed genetic maps using interspecific Mus crosses facilitates rapid analysis of murine genomic organization and may enable physical mapping of syntenic regions within the human genome. Moreover, the data suggest profound conservation of genomic organization during mammalian evolution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 75-83 |
| Number of pages | 9 |
| Journal | Genomics |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Long-range restriction site mapping of a syntenic segment conserved between human chromosome 1 and mouse chromosome 3. / Kingsmore, Stephen F.; Moseley, Walton S.; Watson, Mark L.; Sabina, Richard L.; Holmes, Edward W.; Seldin, Michael F.
In: Genomics, Vol. 7, No. 1, 1990, p. 75-83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-range restriction site mapping of a syntenic segment conserved between human chromosome 1 and mouse chromosome 3
AU - Kingsmore, Stephen F.
AU - Moseley, Walton S.
AU - Watson, Mark L.
AU - Sabina, Richard L.
AU - Holmes, Edward W.
AU - Seldin, Michael F
PY - 1990
Y1 - 1990
N2 - A linkage map determined from segregation analysis of 338 meiotic events in an interspecific mouse cross was utilized to help investigate genomic organization of a linkage group conserved between human chromosome 1p and mouse chromosome 3. Using pulsedfield gel electrophoresis, the genes encoding the lymphocyte adhesion molecule human CD2/murine Ly-37, the α1-subunit of Na, K-ATPase, the β-subunit of thyrotropin, the β-subunit of nerve growth factor, and muscle adenylate deaminase were similarly positioned on long-range restriction maps in both species. These studies indicate that the development of detailed genetic maps using interspecific Mus crosses facilitates rapid analysis of murine genomic organization and may enable physical mapping of syntenic regions within the human genome. Moreover, the data suggest profound conservation of genomic organization during mammalian evolution.
AB - A linkage map determined from segregation analysis of 338 meiotic events in an interspecific mouse cross was utilized to help investigate genomic organization of a linkage group conserved between human chromosome 1p and mouse chromosome 3. Using pulsedfield gel electrophoresis, the genes encoding the lymphocyte adhesion molecule human CD2/murine Ly-37, the α1-subunit of Na, K-ATPase, the β-subunit of thyrotropin, the β-subunit of nerve growth factor, and muscle adenylate deaminase were similarly positioned on long-range restriction maps in both species. These studies indicate that the development of detailed genetic maps using interspecific Mus crosses facilitates rapid analysis of murine genomic organization and may enable physical mapping of syntenic regions within the human genome. Moreover, the data suggest profound conservation of genomic organization during mammalian evolution.
UR - http://www.scopus.com/inward/record.url?scp=0025040046&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025040046&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(90)90520-5
DO - 10.1016/0888-7543(90)90520-5
M3 - Article
C2 - 1970802
AN - SCOPUS:0025040046
VL - 7
SP - 75
EP - 83
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 1
ER -